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GD3 ganglioside checkpoints in immune surveillance of senescent cells

Nature
Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells.
1 day ago

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging

Nature
Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can...
3 weeks ago

Sugar Auxiliary Group Assisted Diversity-Oriented Enzymatic Modular Synthesis of 0-Series Ganglioside Glycans

Wiley Online Library
Owing to the inaccessibility of β1–4-N-acetylgalactosaminyltransferase for direct glycan chain elongation, the enzymatic synthesis of 0-series gangliosides...
3 weeks ago

Figure 6. In situ MALDI MSI analysis of gangliosides in mouse brain...

ResearchGate
Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain
1 month ago

Emerging Sialylated Class R Lipooligosaccharides in Campylobacter jejuni from Seagulls Has the Potential to Trigger Guillain-Barré Syndrome — Yunnan Province, China, 2018–2023

China CDC Weekly
Lipooligosaccharides from Campylobacter jejuni (C. jejuni) have a mimicry antigen structure with gangliosides, which explains the mechanism by which C.
2 months ago

Deciphering mouse brain spatial diversity via glyco-lipidomic mapping

Nature
Gangliosides in the brain play a crucial role in modulating the integrity of vertebrate central nervous system in a region-specific manner.
3 months ago

Detection of N-Glycolyl GM3 Ganglioside in Neuroectodermal Tumors by Immunohistochemistry: An Attractive Vaccine Target for Aggressive Pediatric Cancer

Wiley Online Library
The N-glycolylated ganglioside NeuGc-GM3 has been described in solid tumors such as breast carcinoma, nonsmall cell lung cancer, and melanoma,...
5 months ago

MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Kidney Tissue Abscesses

ACS Publications
Gangliosides play important roles in innate and adaptive immunity. The high degree of structural heterogeneity results in significant variability in...
5 months ago

Ganglioside GM3-based anticancer vaccines: Reviewing the mechanism and current strategies

ScienceDirect.com
This review summarizes the studies on the recent efforts to development GM3-based anticancer vaccines.
5 months ago

Differential effects of ganglioside lipids on the conformation and aggregation of islet amyloid polypeptide

Wiley Online Library
We seek here to characterize the effects of three gangliosides, the dominant anionic lipids in the outer leaflet of the plasma membrane, on the aggregation,...
6 months ago