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Figure 6. In situ MALDI MSI analysis of gangliosides in mouse brain...

ResearchGate
Gangliosides are ubiquitously present on cell surface. They are more abundantly expressed in nerve cells and tissues and involved in pathology of various...
3 days ago

MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Kidney Tissue Abscesses

ACS Publications
Here, ganglioside structural and spatial heterogeneity within an S. aureus-infected mouse kidney abscess was characterized.
4 months ago

The biological role and immunotherapy of gangliosides and GD3 synthase in cancers

Frontiers
This review summarizes the function, molecular mechanisms, and ongoing clinical applications of GD3, GD2, and GD3S in abundant types of tumors
5 months ago

Integrated chemoenzymatic synthesis of a comprehensive sulfated ganglioside glycan library to decipher functional sulfoglycomics and sialoglycomics

Nature
Here we report an integrated chemoenzymatic strategy for expeditious and systematic synthesis of a comprehensive 65-membered ganglioside glycan library
5 months ago

Ganglioside GM3-based anticancer vaccines: Reviewing the mechanism and current strategies

ScienceDirect.com
This review summarizes the studies on the recent efforts to development GM3-based anticancer vaccines.
4 months ago

Differential effects of ganglioside lipids on the conformation and aggregation of islet amyloid polypeptide

Wiley Online Library
We seek here to characterize the effects of three gangliosides, the dominant anionic lipids in the outer leaflet of the plasma membrane, on the aggregation,...
4 months ago

Gangliosides in the Brain: Physiology, Pathophysiology and Therapeutic Applications

Frontiers
Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain.
9 months ago

Emerging Sialylated Class R Lipooligosaccharides in Campylobacter jejuni from Seagulls Has the Potential to Trigger Guillain-Barré Syndrome — Yunnan Province, China, 2018–2023

China CDC Weekly
Lipooligosaccharides from Campylobacter jejuni (C. jejuni) have a mimicry antigen structure with gangliosides, which explains the mechanism...
4 weeks ago

Deciphering mouse brain spatial diversity via glyco-lipidomic mapping

Nature
Gangliosides in the brain play a crucial role in modulating the integrity of vertebrate central nervous system in a region-specific manner.
1 month ago

New gene, new strides in gangliosidosis

American Society for Biochemistry and Molecular Biology
GM1 gangliosidosis is caused by mutations in the GLB1 gene that codes for an enzyme called lysosomal β-galactosidase. This enzyme breaks down a lipid called GM...
5 months ago