GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside accumulation into the lysosome due to mutations on the genes encoding for the ...
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In organic chemistry, GM2 is a type of ganglioside. G refers to ganglioside, the M is for monosialic and 2 refers to the fact that it was the second ...
Ganglioside GM2 refers to a type of ganglioside that accumulates in various tissues due to a defect in the enzyme that degrades it, leading to neurological ...
Sep 12, 2024 · This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A.
GM2 gangliosidoses are a group of sphingolipidoses characterized by the impairment of lysosomal activity β-hexosaminidases A and B, or the GM2 activator protein ...
Sep 20, 2020 · It has been shown that abnormal accumulation of GM2 ganglioside in neurons leads to cytoplasmic vacuolation and progressive neurodegeneration, ...
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This human ganglioside GM2 preperation was isolated from brain tissue of a patein who died of Sandhoff's disease.
Mar 28, 2024 · The GM2A gene provides instructions for making a protein called the ganglioside GM2 activator. This protein is necessary for the normal function of an enzyme ...
Function. GM2 gangliosides are components of the cell membrane and may suppress malignant properties of various cancers. The mechanism is suggested to be due to ...
GM2 is a tumor associated antigen (TAA) overexpressed on the surface of many cancer cells, such as multiple myeloma (MM) cells and neuroblastoma cells.
