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The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2

ASM Journals
In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein.
5 months ago

Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor

Nature
Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and...
11 months ago

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

Frontiers
Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional...
10 months ago

H2 blockers: Types, uses, and side effects

MedicalNewsToday
H2 blockers are an effective treatment. They bind to histamine receptors in the stomach, reducing the amount of acid that the stomach lining secretes.
58 months ago

Heartburn medication update

Harvard Health
H2 blockers — such as famotidine (Pepcid) and cimetidine (Tagamet) — are available over the counter or by prescription...
54 months ago

Should we be taking first-generation H1-antihistamines, like Benadryl, off the over-the-counter shelves?

Healthy Debate
For years, Benadryl has been used as the go-to drug to treat a range of allergic reactions. But many experts are now discouraging its use...
60 months ago

Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells

Nature
Abstract. Cancer therapy is often hampered by the disease's development of resistance to anticancer drugs. ... Here we show that cloperastine and...
46 months ago

Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns

Frontiers
Our study confirms that cetirizine combined with midazolam and fentanyl reduces catecholamine surge and liver and lung damage after severe burns in rats.
10 months ago

Histamine modulation of urinary bladder urothelium, lamina propria and detrusor contractile activity via H1 and H2 receptors

Nature
Our findings provide evidence that histamine produces contractile responses both in the U&LP and detrusor via the H1-receptor.
69 months ago

Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells

Frontiers
Terfenadine induces the apoptosis of HCT116 cells by abrogating STAT3 signaling. Overall, this study supports terfenadine as a prominent anticancer therapy for...
6 months ago