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The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2

ASM Journals
In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein.
6 months ago

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

Frontiers
Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional...
11 months ago

Molecular mechanism of antihistamines recognition and regulation of the histamine H

Nature
Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and...
12 months ago

Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse

Frontiers
Histamine H3 receptor (H3R) antagonists/inverse agonists possess potential to treat diverse disease states of the central nervous system (CNS).
6 months ago

H2 blockers: Types, uses, and side effects

MedicalNewsToday
H2 blockers are an effective treatment. They bind to histamine receptors in the stomach, reducing the amount of acid that the stomach lining secretes.
59 months ago

Can Antihistamines Help Treat Eczema?

HealthCentral
A go-to for relieving allergy-related itch, these OTC drugs don't necessarily make a dent when it comes to treating symptoms of atopic...
8 months ago

Heartburn medication update

Harvard Health
H2 blockers — such as famotidine (Pepcid) and cimetidine (Tagamet) — are available over the counter or by prescription...
55 months ago

Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells

Nature
Abstract. Cancer therapy is often hampered by the disease's development of resistance to anticancer drugs. ... Here we show that cloperastine and...
47 months ago

Histamine H1 receptor antagonist attenuates catecholamine surge and organ injury after severe burns

Frontiers
Our study confirms that cetirizine combined with midazolam and fentanyl reduces catecholamine surge and liver and lung damage after severe burns in rats.
11 months ago

Brain Activation by H1 Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew)

Frontiers
Mepyramine was a more efficacious anti-emetic than cetirizine, suggesting an important role of centrally-located H 1 receptors.
10 months ago