It is similar to guan- ethidine in many ways and acts by causing a peripheral catecholamine depletion. 7 However, its effect is conSiderably shorter than that of guanethidine, being in the order of 6 to 8 hours." Thus, it would seem possible to achieve a more balanced control of blood pressure throughout the day.
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The two drugs reduced blood pressure about equally well. In light of the efficacy without severe side effects, guanadrel may be an agent for step II therapy of ...
Comparison of guanadrel and guanethidine. Clin Pharmacol Ther. 1973 Mar-Apr;14(2):204-8. doi: 10.1002/cpt1973142204.
Both guanadrel and guanethidine caused a statistically significant reduction of blood pressure when compared to placebo, but there was no significant ...
Adverse effects of guanadrel include edema, dizziness, fluid retention, orthostatic hypotension, drowsiness, diarrhea, nausea, vomiting, and sexual dysfunction.
Jun 13, 2005 · Guanadrel may increase the hypotensive activities of Guanethidine. Guanfacine, Guanfacine may decrease the antihypertensive activities of ...
Feb 14, 2013 · GUANADREL: IT IS RELATED TO GUANETHIDINE BUT HAS DIFFERENT KINETICS ... Article PDF. Download to read the full article text. Use our pre- ...
Guanadrel is an analog of guanethidine with a shorter half-life and a shorter duration of action. Disposition of this drug is significantly altered by renal ...
Apr 6, 2021 · Guanadrel · Effects are less severe than with Guanethidine · Transient Hypertension and Tachycardia (see mechanism above) · Hypotension. Reflex ...
Guanadrel: A New Antihypertensive Drug - JAMA Network
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Apr 24, 1981 · Guanadrel sulfate, a new adrenergic neuron inhibitor similar to guanethidine sulfate, was tested on 199 outpatients by 11 investigators.