Iproniazid, the first modern antidepressant, was originally developed as a drug for the chemotherapy of tuberculosis in the early 1950s. Nathan Kline (1916–1984) observed that iproniazid, in addition to its ability to treat tuberculosis, could elevate mood and stimulate activity in many patients.
History. Iproniazid was originally developed for the treatment of tuberculosis, but in 1952, its antidepressant properties were discovered when researchers ...
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Isoniazid and its derivative iproniazid were introduced in 1951 as pharmacologic treatments for tuberculosis. It was found that iproniazid inhibited the enzyme ...
The 1950s saw the clinical introduction of the first two specifically antidepressant drugs: iproniazid, a monoamine-oxidase inhibitor that had been used in ...
While developing new antitubercular compounds, Fox and Gibas (1953) synthesized isopropyl-isonicotinyl hydrazide (iproniazid), a monoalkyl derivative of ...
Feb 27, 2021 · Dr. Kline first reported in 1957 the beneficial effects of iproniazid, a monoamine oxidase inhibitor, in the treatment of severe depression.
Iproniazid, the first drug of the monoamine-oxidase inhibitor series to be introduced into medicine (1958). It was employed as an antidepressant until it was ...
Jan 27, 2016 · A drug designed to kill the bacteria that causes tuberculosis was serendipitously found to improve mood and invoke joy.
Jan 1, 1979 · The discovery of iproniazid or 1-isonicotinyl 2-isopropyl hydrazine (trade name, Marsalid) constitutes a notable case of serendipity of great ...
... iproniazid. Its introduction as the first modern antidepressant was based on three unexpected actions of the drug: MAO-inhibition, 'reversal' of reserpine ...
