By means of its proteolytic activity, PAPP-A functions as a regulatory protein in the insulin-like growth factor system, known to be important for placental formation and regulation of fetal growth.
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PAPP-A is also a glycoprotein, which is mainly produced by syncytiotrophoblast[8] and may affect placental function through insulin-like growth factors ...
[PDF] PAPP-A (Pregnancy associated plasma protein-A)
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It is needed for the implantation process and to maintain a healthy placenta (afterbirth). PAPP-A is a marker measured as part of the combined pregnancy ...
Mar 20, 2020 · PAPP-A is a metalloproteinase that cleaves three insuline growth factor binding protein (IGFBP):IGFBP-2, -4 and -5; it binds to the surface of ...
Pregnancy-associated plasma protein A ... PaPP-A is a marker of neovascularization that may also play a role in detecting atherosclerosis and plaque rupture.
PAPPA's proteolytic function is activated upon collagen binding. It is thought to be involved in local proliferative processes such as wound healing and bone ...
Dec 31, 2010 · By means of its proteolytic activity, PAPP-A functions as a regulatory protein in the insulin-like growth factor system, known to be important ...
Pregnancy-associated plasma protein-A (PAPP-A)was discovered in 1972 as an antigen present in human pregnancy plasma with no known function or activity.
Mar 20, 2018 · This protein is thought to have several different functions, including preventing recognition of the fetus by the maternal immune system, matrix ...
Sep 13, 2019 · Pregnancy-associated plasma protein-A (PAPP-A) is a key regulator of insulin-like growth factor (IGF) bioactivity, by releasing the IGFs ...
