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Role of Basophils in a Broad Spectrum of Disorders

Frontiers
Basophils infiltrate inflamed tissues of patients with various disorders, even though they circulate in the bloodstream under homeostatic conditions.
7 months ago

PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

Nature
Our study establishes a direct mechanistic link between basophils and TFH cells in SLE that promotes autoantibody production and lupus nephritis.
5 months ago

Basophils: Basophil Function, Origin and Related Conditions

Technology Networks
Basophils are a type of immune cell that belong to the granulocyte group along with neutrophils and eosinophils. They were first described by...
10 months ago

Evaluation of peripheral basophil activation during exercise provocation test for desensitized patients

Frontiers
This study investigated basophil activation status during the exercise provocation test (EPT) performed to diagnose EIARD.
3 months ago

Targeting basophils to revitalize cytotoxic T-cells in tumor microenvironment

News-Medical
Targeting tumor-associated basophils represents a promising avenue for enhancing antitumor immunity and improving patient outcomes.
3 months ago

Secret Relationship of Regulatory T cells, Tregs, on Basophils

MedicalResearch.com
We found that Tregs stimulate resting basophils to induce the expression of activation markers CD69, CD203c, and CD13, and release cytokines IL-4, IL-8, and IL...
3 months ago

Burton line and basophilic stippling in lead poisoning

CMAJ
These small, punctate inclusions, derived from ribosomes or ribosomal RNA fragments, are classically associated with lead poisoning.
5 months ago

"Differentiation trajectory and regulatory functions of basophils identified by single-cell RNA-seq analysis."

BioSpectrum Asia
In this seminar, I will talk about the recent advancements in basophil biology clarified by single-cell RNA-seq analysis.
7 months ago

Basophils absence predicts poor prognosis and indicates immunosuppression of patients in intensive care units

Nature
We identify basophils absence during ICU stay as a novel and unfavorable indicator for evaluating the prognosis of ICU patients.
11 months ago

Pilot study on the use of basophil activation tests and skin tests for the prevention of allergic transfusion reactions

Frontiers
In this study, we investigate the usefulness of skin tests and basophil activation tests (BAT) in chronically transfused patients for the prevention of future...
3 months ago