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Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2

Nature
Our work reveals a novel covalent exosite-competitive inhibition mechanism of PAPP-A and its regulatory effect on placental function.
23 months ago

Study on the association between pregnancy-associated plasma protein-A and acute cerebral infarction

Frontiers
The level of plasma PAPP-A could be the independent risk factor of ACI. It is positively correlated with triglyceride and cholesterol content.
9 months ago

Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2

Breast Cancer Research
We show that PAPP-A activates the collagen receptor DDR2 and metastasis. Further, deletion of DDR2 by CRISPR abolished the effect of PAPP-A on invasion.
67 months ago

Pregnancy-Associated Plasma Protein A as a Marker of Acute Coronary Syndromes

The New England Journal of Medicine
We evaluated pregnancy-associated plasma protein A (PAPP-A), a potentially proatherosclerotic metalloproteinase, as a marker of acute coronary syndromes.
79 months ago

Importance of Low Pregnancy Associated Plasma Protein-A (PAPP-A) Levels During the First Trimester as a Predicting Factor for Adverse Pregnancy Outcomes: A Prospective Cohort Study of 2636 Pregnant Women

Cureus
Results: PAPP-A levels of ≤0.4 MoM were associated with increased maternal body mass index (BMI), increased uterine arteries pulsatility index (...
24 months ago

Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells

Wiley Online Library
A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse...
45 months ago

Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition

Nature
We show that PAPP-A is a flexible trans-dimer that binds IGFBP5 via a 25-amino acid anchor peptide which extends into the metalloprotease active site.
26 months ago

Heritability and circulating concentrations of pregnancy-associated plasma protein-A and stanniocalcin-2 in elderly monozygotic and dizygotic twins

Frontiers
This twin study confirms our hypothesis that the heritability of PAPP-A serum concentrations is substantial, and the same is true for STC2.
18 months ago

PP13 and PAPP‐A in the First and Second Trimesters: Predictive Factors for Preeclampsia?

Wiley Online Library
In this study we showed that the pregnancy-associated plasma protein-A (PAPP-A) has been lower in both first and second trimesters among women who developed...
149 months ago

Aberrant pregnancy-associated plasma protein-A expression in breast cancers prognosticates clinical outcomes

Nature
Elevated levels of pregnancy-associated plasma protein-A (PAPP-A) have been implicated in the pathogenesis of various malignancies,...
51 months ago