The main effect of calcium channel blockers is the blockade of calcium entry into cells through voltage operated calcium channels. This volume gives a comprehensive overview of the different classes of CCBs and their various effects.

This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels.

This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel.

This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research.

Held at Boppard, Germany, October 3-6, 1984

The major aim of the present book is to present the clinician with the information needed for the practical use of calcium antagonists. What do all the numerous and often conflicting trials say? Do these agents really work?

Cells are suspended in media of different Ca+ con 2 2 tent whose Ca+ concentration is monitored by a Ca+ -selective electrode. When the cells are lysed (by digitonin) there is an upward or downward deflection of the elec 2 trode signal.

These achievements on effectiveness have been accompanied by reduced effects when compared with classical calcium antagonists. Most interestingly, this book examines new calcium channel blockers, which may effect kidney microcirculation.