This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine.

In planning the book we made great use of the excellent and classical mono graph by W. FELDBERG and E. SCHILF on Histamin, published by Julius Springer, in 1930.

In planning the book we made great use of the excellent and classical mono graph by W. FELDBERG and E. SCHILF on Histamin, published by Julius Springer, in 1930.

This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists.

Together with the two previous volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines the present publication yields a picture of a still rapidly developing field of research.

Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al.

In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions.

The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites.