- Istanbul, İstanbul, Turkey
- Forensic Science, Criminalistica Y Ciencias Forenses, Forensic Psychology, Forensics, Forensic chemistry, Crime, and 12 moreCrime Science, Criminology, Expert evidence, Mitochondrial DNA, DNA (Forensic Science), Biology, Drugs And Addiction, Drug Trafficking, Organized Crime, International Organized Crime, Crime Prevention, and Prevention Strategiesedit
- United Nations International Narcotics Control Board Memberedit
Significant genetic variation in populations can occur as a result of differential gene flow from neighboring populations. In a sociological study of people living in Turkey, 47 different ethnic groups are listed (Andrews, 1989). The... more
Significant genetic variation in populations can occur as a result of differential gene flow from neighboring populations. In a sociological study of people living in Turkey, 47 different ethnic groups are listed (Andrews, 1989). The present study aims to compare three of them -Sunni Turks, Laz Turks and Hemsinli- with each other.
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The short tandem repeat (STR) systems HumTHOI and Hum VWA were used for PCR typing of two Caucasian subpopulations, one living in the Black sea area (northern Turkey), the other being a subpopulation from eastern Anatolia (eastern... more
The short tandem repeat (STR) systems HumTHOI and Hum VWA were used for PCR typing of two Caucasian subpopulations, one living in the Black sea area (northern Turkey), the other being a subpopulation from eastern Anatolia (eastern Turkey). The allele frequency data were compared with a turkish subpopulation from Adana area (southern Turkey) and a group of Turks living in Brussels (Belgium). The HumTHOI data showed a significant difference in the Black Sea region compared to the 3 other groups while the subpopulation from the eastern Anatolia showed significant differences in Hum VWA system.
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Significant genetic variation in populations can occur as a result of differential gene flow from neighboring populations. In a sociological study of people living in Turkey, 47 different ethnic groups are listed (Andrews, 1989). The... more
Significant genetic variation in populations can occur as a result of differential gene flow from neighboring populations. In a sociological study of people living in Turkey, 47 different ethnic groups are listed (Andrews, 1989). The present study aims to compare three of them -Sunni Turks, Laz Turks and Hemsinli- with each other.
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YAYIN KURULU Prof. Dr. Wolfgang Gieler, Siegen Universitesi Prof. Dr. Hasan Koni, Istanbul Kultur Universitesi Prof. Dr. Adnan Omerustaoglu, Biruni Universitesi Doc. Dr. Soner Karagul, Canakkale Onsekiz Mart Universitesi Doc. Dr. Cumhur... more
YAYIN KURULU Prof. Dr. Wolfgang Gieler, Siegen Universitesi Prof. Dr. Hasan Koni, Istanbul Kultur Universitesi Prof. Dr. Adnan Omerustaoglu, Biruni Universitesi Doc. Dr. Soner Karagul, Canakkale Onsekiz Mart Universitesi Doc. Dr. Cumhur Tas, Uskudar Universitesi
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In this study, the relationship between Monoamine Oxidase A variable tandem repeat number genetic polymorphism and cognitive tests used for depression and anxiety were evaluated. The study aimed to determine whether Monoamine Oxidase A... more
In this study, the relationship between Monoamine Oxidase A variable tandem repeat number genetic polymorphism and cognitive tests used for depression and anxiety were evaluated. The study aimed to determine whether Monoamine Oxidase A (MAOA) variable sequential repetition count could be an indicator that can be useful in diagnosing depression and anxiety. The beck depression inventory and beck anxiety inventory were applied to 102 individuals aged between 20-25 years. Oral epithelial cells and blood samples were collected for genetic analysis. DNA isolation of blood samples was performed, and the variable number of tandem repeat polymorphism was analyzed. The association between the beck depression and anxiety inventory results variable number of tandem repeat polymorphisms were evaluated statistically by the chi-square test or fisher’s exact test. While the results obtained proved a statistically significant relationship between Monoamine Oxidase A (MAOA) variable tandem repeat nu...
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hakemli bir dergidir. Makalelerdeki düşünce, görüş ve varsayımlar eser sahiplerine aittir; Üsküdar Üniversitesi sorumlu tutulamaz. ÜSKÜDAR ÜNİVERSİTESİ SOSYAL BİLİMLER DERGİSİ (ÜSBİD) Yıl 1 · Sayı 1 · Kasım 2015 · ISSN Üsküdar... more
hakemli bir dergidir. Makalelerdeki düşünce, görüş ve varsayımlar eser sahiplerine aittir; Üsküdar Üniversitesi sorumlu tutulamaz. ÜSKÜDAR ÜNİVERSİTESİ SOSYAL BİLİMLER DERGİSİ (ÜSBİD) Yıl 1 · Sayı 1 · Kasım 2015 · ISSN Üsküdar Üniversitesi adına Sahibi
Background Among the physical evidence, bloodstain is one of the most common biological pieces of evidence at the crime scene, especially in violent crimes. Bloodstains are frequently seen at the crime scene and can be easily detected due... more
Background Among the physical evidence, bloodstain is one of the most common biological pieces of evidence at the crime scene, especially in violent crimes. Bloodstains are frequently seen at the crime scene and can be easily detected due to their color and structure. Because blood and bloodstains can potentially be evidence of a crime, offenders often tend to clean or wash them to get rid of relevant evidence. Some researchers think that washed bloodstains cannot obtain enough quality DNA for DNA profiling. However, some studies have shown that bloodstains on a piece of fabric can be used for DNA profiling even after washing. This study, it is aimed to determine whether a sufficient amount of DNA can be obtained for DNA profiling used for forensic purposes from blood-stained nylon and cotton fabrics washed at different temperatures such as 40 °C, 60 °C and 90 °C. Results In this study, bloodstains were created on cotton and nylon fabrics in a representative crime scene. After washi...
Analysis of 89 biallelic polymorphisms in 523 Turkish Y chromosomes revealed 52 distinct haplotypes with considerable haplogroup substructure, as exemplified by their respective levels of accumulated diversity at ten short tandem repeat... more
Analysis of 89 biallelic polymorphisms in 523 Turkish Y chromosomes revealed 52 distinct haplotypes with considerable haplogroup substructure, as exemplified by their respective levels of accumulated diversity at ten short tandem repeat (STR) loci. The major components
Legal medicine in Turkey, has an educational background that goes back to 1839 and the first autopsy in modern terms was performed in 1841. In the early days, it was common practice for those involved in this work to extend their... more
Legal medicine in Turkey, has an educational background that goes back to 1839 and the first autopsy in modern terms was performed in 1841. In the early days, it was common practice for those involved in this work to extend their investigative knowledge into areas not directly concerned with medical matters. However forensic medical investigations cannot be entrusted in the hands of single investigators, but should rather be dealt with by cooperative groups of experts nowadays. This need was the major force for the establishment of the Institute of Legal Medicine and Forensic Sciences by a special article of the law (section 2547) as a training and research center in 1982. The Institute being the first and only institution giving master's and doctorate degrees in Forensic Sciences, has 3 major departments: 1) Medical Sciences Department, 2) Basic Sciences Department and 3) Social Sciences Department. Graduates of various fields ranging from medical doctors specialized in any fie...
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Istanbul is the most densely populated city of Turkey, with approximately 16 million inhabitants. A local STR database for the population of the city of Istanbul was generated in this study. We analyzed blood samples of 311 volunteer... more
Istanbul is the most densely populated city of Turkey, with approximately 16 million inhabitants. A local STR database for the population of the city of Istanbul was generated in this study. We analyzed blood samples of 311 volunteer individuals. Aiming to avoid forming a criminal subgroup, we selected from these people who had not committed any crime. DNA was extracted using Chelex 100 extraction method (1) and the typing was performed using the Gene print STR systems according to the manufacturer's instructions. The detection was done by silver staining. The statistical analysis revealed no significant deviation from Hardy Weinberg expectations. Parameters like observed and expected heterozygosity, power of exclusion and discrimination, probability of match, paternity index as well as a detailed comparison with various populations (2) are available at http://istanbul.edu.tr/enstituler/ forensic/popgen-01.htm .
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This study is part of a general survey in which the regional variability of various genetic markers in Turkey will be analyzed with special regard to its application in forensic medicine. Blood samples from 3173 unrelated healthy... more
This study is part of a general survey in which the regional variability of various genetic markers in Turkey will be analyzed with special regard to its application in forensic medicine. Blood samples from 3173 unrelated healthy individuals of both sexes and from different regions of Turkey have been sampled and were typed for the blood group polymorphisms AB0, MNSs, Kell, Duffy, Kidd, P, Lutheran and Lewis, for the red cell enzyme polymorphisms adenylate kinase (AK), glyoxalase (GLO), phosphoglucomutase (PGM), esterase D (ESD), red cell acid phosphatase (aP), and for the serum protein polymorphisms group specific component (vitamin D binding protein, GC) and transferrin (TF). In addition to this the HLA-A and HLA-B antigens of the major histocompatibility complex (HLA) were also typed in 973 individuals. The blood group polymorphisms were typed by the classical haemagglutination methods. Serum protein and red cell enzyme polymorphisms were determined by conventional cellulose acetate electrophoresis. HLA antigens were typed by the standard two stage microlymphocytotoxicity technique. Genetic equilibrium can be assumed for all polymorphic systems under study. The results indicate some regional differences in the distribution of allele frequencies.
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Malpractice in breast cancer can be seen as false negative or false positive findings which may result to either late or wrong therapies. Bioptic material can be unintentionally interchanged, leading to a completely wrong treatment,... more
Malpractice in breast cancer can be seen as false negative or false positive findings which may result to either late or wrong therapies. Bioptic material can be unintentionally interchanged, leading to a completely wrong treatment, together with a psychological damage to the patient. There is an obvious need for the individualization of the tissue samples in such cases. In this study we used a multidisciplinary approach to integrate DNA technology that has been standardized and used and in forensic sciences to prove malpractice that has been the result of interchanging tissue samples in breast cancer. The main focus of the study was to evaluate the applicability of the technique to cases therefore we used as an example of an 58 years old lady for whom the result of pathological analysis was reported as "invasive ductal carcinoma". The patient was surgically treated by a modified mastectomy technique and referred for chemotherapy. Prior to chemotherapy we found out that th...
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Effects of gamma-vinyl-GABA (GVG), an antiepileptic drug that inhibits GABA transaminase and increases extracellular GABA concentrations in the brain, were investigated on the morphine abstinence syndrome (AS) in male Wistar rats. Two... more
Effects of gamma-vinyl-GABA (GVG), an antiepileptic drug that inhibits GABA transaminase and increases extracellular GABA concentrations in the brain, were investigated on the morphine abstinence syndrome (AS) in male Wistar rats. Two morphine pellets (75 mg morphine base in each) were implanted subcutaneously on the back of the rats. Seventy-two hours after the morphine implantation, naloxone (NL, 2 mg kg-1) was injected intraperitoneally (i.p.) to induce precipitated morphine AS. GVG was administered at the doses of 250 mg kg-1 (n = 11) and 500 mg kg-1 (n = 11) i.p. 24 h prior to AS and at the dose of 500 mg kg-1 (n = 13) i.p. 6 h prior to AS. Immediately after NL injections, rats were observed for 5 min and AS signs (jumping, teeth chattering, wet dog shake, diarrhoea, ptosis and defecation) were assessed. The behavioural signs of GVG-treated rats were compared with the control groups (n = 10) during the AS. Jumping, wet dog shake, teeth chattering were found to be significantly increased in all of the GVG-treated groups. Ptosis was found to have increased in only 500 mg kg-1 GVG groups. GVG potentiated the severity of morphine AS signs. GVG does not seem to have any therapeutic potential for treatment of morphine abstinence unlike some other drugs that enhance GABAergic transmission.
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The earliest Neolithic sites of Europe are located in Crete and mainland Greece. A debate persists concerning whether these farmers originated in neighboring Anatolia and the role of maritime colonization. To address these issues 171... more
The earliest Neolithic sites of Europe are located in Crete and mainland Greece. A debate persists concerning whether these farmers originated in neighboring Anatolia and the role of maritime colonization. To address these issues 171 samples were collected from areas near three known early Neolithic settlements in Greece together with 193 samples from Crete. An analysis of Y-chromosome haplogroups determined that the samples from the Greek Neolithic sites showed strong affinity to Balkan data, while Crete shows affinity with central/Mediterranean Anatolia. Haplogroup J2b-M12 was frequent in Thessaly and Greek Macedonia while haplogroup J2a-M410 was scarce. Alternatively, Crete, like Anatolia showed a high frequency of J2a-M410 and a low frequency of J2b-M12. This dichotomy parallels archaeobotanical evidence, specifically that while bread wheat (Triticum aestivum) is known from Neolithic Anatolia, Crete and southern Italy; it is absent from earliest Neolithic Greece. The expansion time of YSTR variation for haplogroup E3b1a2-V13, in the Peloponnese was consistent with an indigenous Mesolithic presence. In turn, two distinctive haplogroups, J2a1h-M319 and J2a1b1-M92, have demographic properties consistent with Bronze Age expansions in Crete, arguably from NW/W Anatolia and Syro-Palestine, while a later mainland (Mycenaean) contribution to Crete is indicated by relative frequencies of V13.
Research Interests: Ancient History, Population Genetics, Principal Component Analysis, Turkey, Population Dynamics, and 14 moreMolecular Anthropology, Greece, Phylogeny, Humans, Haplotypes, Male, Cluster Analysis, Y chromosome, Ethnic Groups, Clinical Sciences, Annals of Human Genetics, Analysis of Variance, Molecular Archaeology, and Ancient DNA of Human Populations
Analysis of 89 biallelic polymorphisms in 523 Turkish Y chromosomes revealed 52 distinct haplotypes with considerable haplogroup substructure, as exemplified by their respective levels of accumulated diversity at ten short tandem repeat... more
Analysis of 89 biallelic polymorphisms in 523 Turkish Y chromosomes revealed 52 distinct haplotypes with considerable haplogroup substructure, as exemplified by their respective levels of accumulated diversity at ten short tandem repeat (STR) loci. The major components (haplogroups E3b, G, J, I, L, N, K2, and R1; 94.1%) are shared with European and neighboring Near Eastern populations and contrast with only a minor share of haplogroups related to Central Asian (C, Q and O; 3.4%), Indian (H, R2; 1.5%) and African (A, E3*, E3a; 1%) affinity. The expansion times for 20 haplogroup assemblages was estimated from associated STR diversity. This comprehensive characterization of Y-chromosome heritage addresses many multifaceted aspects of Anatolian prehistory, including: (1) the most frequent haplogroup, J, splits into two sub-clades, one of which (J2) shows decreasing variances with increasing latitude, compatible with a northward expansion; (2) haplogroups G1 and L show affinities with south Caucasus populations in their geographic distribution as well as STR motifs; (3) frequency of haplogroup I, which originated in Europe, declines with increasing longitude, indicating gene flow arriving from Europe; (4) conversely, haplogroup G2 radiates towards Europe; (5) haplogroup E3b3 displays a latitudinal correlation with decreasing frequency northward; (6) haplogroup R1b3 emanates from Turkey towards Southeast Europe and Caucasia and; (7) high resolution SNP analysis provides evidence of a detectable yet weak signal (<9%) of recent paternal gene flow from Central Asia. The variety of Turkish haplotypes is witness to Turkey being both an important source and recipient of gene flow.