WO2002030410A3 - Suppression of cyclin kinase activity for prevention and treatment of infections - Google Patents

Suppression of cyclin kinase activity for prevention and treatment of infections Download PDF

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Publication number
WO2002030410A3
WO2002030410A3 PCT/US2001/031835 US0131835W WO0230410A3 WO 2002030410 A3 WO2002030410 A3 WO 2002030410A3 US 0131835 W US0131835 W US 0131835W WO 0230410 A3 WO0230410 A3 WO 0230410A3
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WO
WIPO (PCT)
Prior art keywords
infections
suppression
prevention
treatment
kinase activity
Prior art date
Application number
PCT/US2001/031835
Other languages
French (fr)
Other versions
WO2002030410A2 (en
Inventor
Thomas Albrecht
Laurent Meijer
Priscilla Schaffer
Luis Schang
Original Assignee
Univ Texas
Univ Pennsylvania
Thomas Albrecht
Laurent Meijer
Priscilla Schaffer
Luis Schang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Univ Pennsylvania, Thomas Albrecht, Laurent Meijer, Priscilla Schaffer, Luis Schang filed Critical Univ Texas
Priority to AU2002213132A priority Critical patent/AU2002213132A1/en
Publication of WO2002030410A2 publication Critical patent/WO2002030410A2/en
Publication of WO2002030410A3 publication Critical patent/WO2002030410A3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents

Abstract

The present invention relates to methods for use in treating or preventing infections. More particularly, the invention relates to methods for screening for modulators that inhibit cyclin-dependent kinase and the use of these putative inhibitors to control proliferation of a DNA virus that is dependent upon events associated with cell proliferation for replication. The DNA virus includes any of the herpesvirus family, and most particularly human cytomegalovirus.
PCT/US2001/031835 2000-10-10 2001-10-10 Suppression of cyclin kinase activity for prevention and treatment of infections WO2002030410A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002213132A AU2002213132A1 (en) 2000-10-10 2001-10-10 Suppression of cyclin kinase activity for prevention and treatment of infections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68598600A 2000-10-10 2000-10-10
US09/685,986 2000-10-10
US30418500P 2000-10-11 2000-10-11
US60/304,185 2000-10-11

Publications (2)

Publication Number Publication Date
WO2002030410A2 WO2002030410A2 (en) 2002-04-18
WO2002030410A3 true WO2002030410A3 (en) 2002-07-11

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031835 WO2002030410A2 (en) 2000-10-10 2001-10-10 Suppression of cyclin kinase activity for prevention and treatment of infections

Country Status (2)

Country Link
AU (1) AU2002213132A1 (en)
WO (1) WO2002030410A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2616353A1 (en) * 2005-07-28 2007-02-08 University Of Massachusetts Glucose transport-related genes, polypeptides, and methods of use thereof
AU2022214429A1 (en) 2021-02-01 2023-09-14 Regenxbio Inc. Gene therapy for neuronal ceroid lipofuscinoses
CN117379432B (en) * 2023-12-12 2024-03-08 北京大学 Application of compound or medicinal salt thereof in preparing medicament for treating and preventing diseases caused by porcine pseudorabies virus

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002266A1 (en) * 1984-10-12 1986-04-24 United States Of America, Represented By The Unite Use of suramin for clinical treatment of infection with any of the members of the family of human t-cell leukemia (htlv) viruses including lymphadenopathy virus (lav)
WO1990001935A1 (en) * 1988-08-26 1990-03-08 Michel Vandevelde Use of an agent active against retrovirus and products so produced
WO1997016447A1 (en) * 1995-10-31 1997-05-09 Mitotix, Inc. Inhibitors of cyclin-dependent kinases
WO1998039007A1 (en) * 1997-03-03 1998-09-11 Board Of Regents, The University Of Texas System Supression of cyclin kinase 2 activity for prevention and treatment of dna viral infections
WO1999030710A1 (en) * 1997-12-13 1999-06-24 Bristol-Myers Squibb Company USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDENT KINASE INHIBITORS
WO1999062503A2 (en) * 1998-05-29 1999-12-09 Cnrs (Centre National De Recherche Scientifique) France Innovation Scientifique Et Transfert Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases
WO2001037819A2 (en) * 1999-11-23 2001-05-31 Centre National De La Recherche Scientifique (C.N.R.S.) Use of indirubine derivatives for making medicines
FR2804959A1 (en) * 2000-02-15 2001-08-17 Centre Nat Rech Scient USE OF PAULLON DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS
WO2001060367A1 (en) * 2000-02-15 2001-08-23 University Of Iowa Research Foundation Compositions comprising flavopiridol and their use for hiv therapy

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002266A1 (en) * 1984-10-12 1986-04-24 United States Of America, Represented By The Unite Use of suramin for clinical treatment of infection with any of the members of the family of human t-cell leukemia (htlv) viruses including lymphadenopathy virus (lav)
WO1990001935A1 (en) * 1988-08-26 1990-03-08 Michel Vandevelde Use of an agent active against retrovirus and products so produced
WO1997016447A1 (en) * 1995-10-31 1997-05-09 Mitotix, Inc. Inhibitors of cyclin-dependent kinases
WO1998039007A1 (en) * 1997-03-03 1998-09-11 Board Of Regents, The University Of Texas System Supression of cyclin kinase 2 activity for prevention and treatment of dna viral infections
WO1999030710A1 (en) * 1997-12-13 1999-06-24 Bristol-Myers Squibb Company USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDENT KINASE INHIBITORS
WO1999062503A2 (en) * 1998-05-29 1999-12-09 Cnrs (Centre National De Recherche Scientifique) France Innovation Scientifique Et Transfert Use of indigoid bisindole derivatives for the manufacture of a medicament to inhibit cyclin dependent kinases
WO2001037819A2 (en) * 1999-11-23 2001-05-31 Centre National De La Recherche Scientifique (C.N.R.S.) Use of indirubine derivatives for making medicines
FR2804959A1 (en) * 2000-02-15 2001-08-17 Centre Nat Rech Scient USE OF PAULLON DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS
WO2001060367A1 (en) * 2000-02-15 2001-08-23 University Of Iowa Research Foundation Compositions comprising flavopiridol and their use for hiv therapy

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BRESNAHAN W A ET AL: "INHIBITION OF CELLULAR CDK2 ACTIVITY BLOCKS HUMAN CYTOMEGALOVIRUS REPLICATION", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 231, 1997, pages 239 - 247, XP002922856, ISSN: 0042-6822 *
CHAO S-H ET AL: "FLAVOPIRIDOL INHIBITS P-TEFB AND BLOCKS HIV-1 REPLICATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 275, no. 37, 15 September 2000 (2000-09-15), pages 28345 - 28348, XP000986289, ISSN: 0021-9258 *
GRAESER, R. ET AL.: "Plasmodium falciparum protein kinase 5 and the malarial nuclear division cycles", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 82, no. 1, 12 November 1996 (1996-11-12), pages 37 - 49, XP001069211 *
GRAY N ET AL: "ATP-SITE DIRECTED INHIBITORS OF CYCLIN-DEPENDENT KINASES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 6, no. 9, September 1999 (1999-09-01), pages 859 - 875, XP000856195, ISSN: 0929-8673 *
KITAGAWA, M. ET AL: "A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression", ONCOGENE, vol. 9, no. 9, September 1994 (1994-09-01), pages 2549 - 2557, XP001069210 *
KNOCKAERT, M. ET AL.: "Intracellular targetsof cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors", CHEMISTRY AND BIOLOGY, vol. 7, no. 6, June 2000 (2000-06-01), UK, pages 411 - 422, XP001070114 *
MEIJER L ET AL: "INHIBITION OF CYCLIN-DEPENDENT KINASES, GSK-3SS AND CK1 BY HYMENIALDISINE, A MARINE SPONGE CONSTITUENT", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 7, no. 1, January 2000 (2000-01-01), pages 51 - 63, XP000901413, ISSN: 1074-5521 *
MEIJER L: "CYCLIN-DEPENDENT KINASES INHIBITORS AS POTENTIAL ANTICANCER, ANTINEURODEGENERATIVE, ANTIVIRAL AND ANTIPARASITIC AGENTS", DRUG RESISTANCE UPDATES, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 3, no. 2, 2000, pages 83 - 88, XP000931278, ISSN: 1368-7646 *
SCHANG L M ET AL: "REQUIREMENT FOR CELLULAR CYCLIN-DEPENDENT KINASES IN HERPES SIMPLEXVIRUS REPLICATION AND TRANSCRIPTION", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 7, 1998, pages 5626 - 5637, XP000909412, ISSN: 0022-538X *
SHANG, L., M. ET AL.: "Roscovitine, a specific Inhibitor of Cellular Cyclin-Dependent Kinases,, Inhibits Herpes Simplex Virus DNA Synthesis in the presence of Viral Early Proteins", JOURNAL OF VIROLOGY, vol. 74, no. 5, March 2000 (2000-03-01), USA, pages 2107 - 2120, XP001070109 *
SHANG, L., M. ET AL.: "Transcription of Herpes Simplex Virus Immediate-Early and Early Genes Is Inhibited by Roscovitine, an Inhibitor Specific for Cellular Cyclin-Dependent Kinases", JOURNAL OF VIROLOGY, vol. 73, no. 3, March 1999 (1999-03-01), USA, pages 2161 - 2172, XP001070110 *
VEERANNA ET AL.: "Inhibition of Neuronal Cyclin-Dependent Kinase-5 by Staurosporine and Purine Analogs is Independent of Activation by Munc-18", NEUROCHEMICAL RESEARCH, vol. 21, no. 5, May 1996 (1996-05-01), pages 629 - 636, XP001069208 *
WATERS N.C. ET AL.: "Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparum", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 107, 2000, pages 45 - 55, XP001069206 *

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AU2002213132A1 (en) 2002-04-22
WO2002030410A2 (en) 2002-04-18

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