WO1999067015A1 - Appareil pour la preparation de ciment osseux - Google Patents

Appareil pour la preparation de ciment osseux Download PDF

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Publication number
WO1999067015A1
WO1999067015A1 PCT/DK1998/000208 DK9800208W WO9967015A1 WO 1999067015 A1 WO1999067015 A1 WO 1999067015A1 DK 9800208 W DK9800208 W DK 9800208W WO 9967015 A1 WO9967015 A1 WO 9967015A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
inner chamber
receptor
bone cement
inlets
Prior art date
Application number
PCT/DK1998/000208
Other languages
English (en)
Inventor
Niels Kornerup
Original Assignee
Nikomed Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nikomed Aps filed Critical Nikomed Aps
Priority to AU74255/98A priority Critical patent/AU7425598A/en
Priority to EP98921372A priority patent/EP1035909A1/fr
Publication of WO1999067015A1 publication Critical patent/WO1999067015A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8825—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by syringe details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/565—Mixing liquids with solids by introducing liquids in solid material, e.g. to obtain slurries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5012—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use adapted to be mounted during use on a standard, base or support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75425—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers
    • B01F35/754251—Discharge mechanisms characterised by the means for discharging the components from the mixer using pistons or plungers reciprocating in the mixing receptacle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
    • A61B17/8822—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/8802—Equipment for handling bone cement or other fluid fillers
    • A61B17/8833—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
    • A61B2017/8838—Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means for mixing bone cement or fluid fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2002/4685—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by means of vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/20—Mixing of ingredients for bone cement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms

Definitions

  • the present invention relates to an apparatus for preparing bone cement from two or more constituents contained in respective sealed containers.
  • An apparatus of the present type usually comprises a cylindrical syringe housing in which a stirring piston is present by means of which the two constituents usually constituting a liquid constituent and a powder constituent are mixed after the constituents are introduced into the interior of the housing.
  • the housing also includes a piston body by means of which the bone cement mixture prepared in the apparatus may be expelled by means of an applicator gun through an ejector tube.
  • the constituents from which the bone cement is to be prepared are readily introduced into an inner chamber of the apparatus by breaking the sealed containers in which the constituents are contained and simply pouring the constituents into the interior of the apparatus through one or more funnels.
  • An example of the bone cement to be prepared by means of an apparatus of this kind is the commercial bone cement mixture manufactured by the US company Schering-Plough and sold under the tradename PALACOS ® R. It has been realized that the constituents from which the bone cement is to be prepared are highly toxic and may cause injuries to the person or persons preparing the bone cement from the constituents by means of an apparatus of the above described type.
  • the entire apparatus is to be contained in an evacuated chamber in which the bone cement is to be prepared: however, this technical solution is inconvenient as the preparation of the bone cement from the two or more constituents involves a mechanical mixing of the constituents together which necessitates that the person or persons preparing the bone cement mixture is able to mechanically operate the apparatus and perform a physical work by means of a mixing or stirring piston of the apparatus.
  • the toxic gases and the toxic or skin-irritating powder constituents are stated to be prevented from contacting the person or persons preparing the bone cement mixture from the constituents by evacuating the interior of the mixing apparatus by means of a vacuum source; however, experiments performed by the applicant have clearly demonstrated that liberation of toxic gases and expelling of powder material from the mixing chamber cannot be prevented, even in case the mixing chamber is evacuated by means of a vacuum source.
  • An object of the present invention is to provide an apparatus of the above described kind for preparing a bone cement mixture from two or more constituents, at least one of which constitutes a toxic or skin- irritating constituent, which apparatus prevents the constituents from which the bone cement mixture is to be prepared, at least the toxic or skin- irritating constituent, from being liberated or expelled from the apparatus during any step of the process of preparing the bone cement mixture.
  • An advantage of the present invention relates to the fact that the bone cement preparing and mixing apparatus according to the present invention allows the constituents from which the bone cement mixture is to be prepared to be introduced into the mixing or preparing apparatus without leaking gas, liquid or powder material to the atmosphere.
  • a particular feature of the present invention relates to the fact that the bone cement preparing apparatus according to the present invention allows all steps of the operation of preparing the bone cement mixture from two or more constituents, at least one of which constitutes a toxic or skin- irritating constituent, in a non-gas-, liquid- and powder-leaking state, which steps involve pouring or introducing the constituents into the apparatus, and mechamcally mixing the constituents together for preparing the bone cement mixture.
  • a particular advantage of the present invention relates to the fact that in the bone cement mixing and preparing apparatus according to the present invention the two or more constituents from which the bone cement mixture is to be prepared are transferred from sealed containers in closed off or sealed receptors to the interior of the apparatus and further mixed in a mechanical mixing operation within the apparatus without leaking gas, liquid or powder to the environment for exposure of the person preparing the mixture or persons present in the vicinity of the bone cement mixing and preparing apparatus from toxic or skin- irritating gases, liquids or powder materials.
  • a further advantage of the present invention relates to the fact that no materials including gaseous, liquid and powder materials are liberated from the bone cement mixing and preparing apparatus during the process of introducing the two or more constituents from which the bone cement is to be mixed into the apparatus and during the process of mixing the constituents together until the bone cement prepared by means of the apparatus according to the present invention is expelled by the surgeon by means of the apparatus constituting an applicator apparatus to be received in an applicator gun for expelling the bone cement.
  • an apparatus for preparing bone cement from two or more constituents contained in respective sealed containers comprising: i) a housing defining opposite first and second ends and an inner cylindrical wall, the first end being open and the second end being closed, ii) a piston body received within the housing and sealing against the inner cylindrical wall, the piston body and the housing together defining an inner chamber of the housing, the piston body being movable from the first end towards the second end for diminishing the inner chamber of the housing, iii) at least two receptor assemblies communicating with the inner chamber of the housing through respective inlets, the inlets being shiftable between an open state and a closed state, in which open state communication is established from the receptor assemblies to the inner chamber of the housing, and in which closed state communication to the inner chamber of the housing through the inlets is blocked, each of the receptor assemblies comprising a receptor for receiving
  • the constituents from which the bone cement mixture is to be prepared are transferred from the sealed containers in which the constituents are initially contained to the inner chamber of the housing of the apparatus, as the sealed containers are received in respective receptors of the receptor assemblies, in which receptors leakage-proof communication from the sealed containers to the inner chamber of the housing is established, allowing transfer of the constituents from the sealed containers to the inner chamber of the housing without risking leaking of gaseous, fluid or solid materials to the environment.
  • the apparatus according to the present invention further provides the advantage of allowing the individual preparing the bone cement mixture to position the constituents within the respective receptor assemblies a fairly long period of time before carrying out the mixing or stirring operation and consequently prepare the apparatus according to the present invention in a ready-to-use-state in which the bone cement mixture is simply prepared within an extremely short period of time including the time for transferring the constituents from the receptor assemblies and stirring the bone cement mixture by means of the stirring means, however, eliminating the time of positioning or arranging the constituents within the respective receptor assemblies.
  • the usual time of solidification of bone cement mixtures are of the order of 5-6 minutes meaning that the bone cement mixture has to be used within a fairly short period of time of the order of 2-4 minutes after the bone cement mixture has been prepared. Therefore, the bone cement mixture cannot be produced in advance but need to be produced at the time the surgeon tells that the bone cement mixture is to be prepared.
  • the overall time spent by the surgeon waiting for the bone cement mixture to be prepared is to a great extent shortened as compared to the prior art bone cement mixture apparatuses as the apparatus according to the present invention as discussed above allows the apparatus to be prepared in a ready-to-use state in which the preparation or production of the bone cement mixture involves the transfer of the constituents from the two receptor assemblies to the housing and the operation of stirring the constituents together.
  • the apparatus according to the present invention may include receptor assemblies fulfilling the objects, advantages and features characteristic of the present invention adapted to specific types and kinds of containers which may be constituted by glass bottles, plastic containers, such as plastic bottles, plastic bags, foil bags, capsules, etc. and allowing that the container scontaining the constituents from which the bone cement is to be prepared to be perforated or opened within the receptor or prior to introducing the container or containers into the respective receptors, and in doing so performing a swift introduction of the container or containers in question into the respective receptors preventing to any substantial extent evaporation or liberation of gases, liquids or powder material from the container or containers.
  • receptor assemblies fulfilling the objects, advantages and features characteristic of the present invention adapted to specific types and kinds of containers which may be constituted by glass bottles, plastic containers, such as plastic bottles, plastic bags, foil bags, capsules, etc. and allowing that the container scontaining the constituents from which the bone cement is to be prepared to be perforated or opened within the receptor or prior to introducing the container or containers into the respective receptors, and
  • the receptor assemblies preferably further comprise respective flexible hoses interconnecting the respective receptors and the respective inlets. Consequently, the individual receptors may easily be handled by the person preparing the bone cement mixture, and handled in any appropriate orientation allowed by the presence of the hoses being flexible hoses interconnecting the receptors and the respective inlets.
  • At least one of the receptor assemblies comprises an openable container constituting the respective receptor for receiving and enclosing the respective sealed container containing one of the constituents constituting a liquid constituent to be expelled from its respective sealed container after breaking the sealed container, or alternatively comprises a funnel-shaped receptor.
  • the receptor is adapted to receive and enclose a sealed container, such as a bottle, e.g. a glass or plastic bottle containing a liquid or powder constituent.
  • the receptor constituted by a funnel- shaped receptor is through its adhesive coating applied to its inner surface adapted to seal against the foil bag and establish a leakage-proof communication from the interior of the foil bag to the inner chamber of the housing of the apparatus for transfer of liquid or powder constituents from the foil bag.
  • the funnel-shaped receptor is foldable and collapsible and has gripping flaps for allowing the foldable and collapsible funnel-shaped receptor to be agitated for promoting the expelling of the powder constituent contained within the foil bag.
  • the stirring means of the apparatus according to the present invention may be constituted by any appropriate means including a stirring body and a stirring rod, or alternatively a stirring body which is operable from outside the housing, e.g. through a threaded connection, a magnetic coupling, etc.
  • the stirring body of the presently preferred embodiment according to the present invention is positioned within the inner chamber and connected to the stirring rod which extends through an opening at the second end of the housing, as a seal is provided at the opening for sealing the stirring rod relative to the housing at the opening for preventing leaking of gaseous, liquid or powder substances or materials through the opening through which the stirring rod extends.
  • the ejector tube of the apparatus according to the present invention may be constituted by a separate component which may be integrally connected to the housing, or alternatively mounted on the housing after the preparation of the bone cement mixture and is shiftable between the first and second state through perforating a perforating foil or wall component prior to ejecting the bone cement mixture from the inner chamber of the housing in which the bone cement mixture is prepared.
  • the ejector tube and the stirring rod of the stirring means are integrated into a single component as the stirring rod is composed of a hollow tube constituting the ejector tube and an inner rod extending lengthwise through the hollow tube defining the first state of the ejector tube and being removable from its position within the hollow tube defining the second state of the ejector tube.
  • the housing of the apparatus according to the present invention may per se have any appropriate configuration fulfilling the purposes of the housing of the apparatus according to the present invention.
  • the cylindrical inner wall of the housing may have any appropriate generator, such as a square, a rectangle, an ellipse, and preferably a circle, meaning that the inner cylindrical wall constitutes a circular-cylindrical inner wall allowing that the piston body be simply constituted by a circular- cylindrical body which in a rotational symmetrical manner readily fits into the inner cylindrical wall of the housing.
  • the piston body is preferably arrestable by means of arresting means relative to the housing at the first end of the housing.
  • the arresting means may be constituted by any per se well-known means within the art, such as a screw rod, a bayonet lock, a locking pin, etc.
  • the shifting of the inlets from the open state to the closed state, and optionally vice versa may be accomplished in any appropriate manner by means of a separate closing element constituting an external component or an internal component of the apparatus, which component may be moved from a position corresponding to the closed state of the inlet to a different position constituting the open state of the inlet.
  • the closing of the inlets and the opening of the inlets need not be accomplished by means of a single element or component providing a simultaneous closing and/or opening of the inlets.
  • the inlets are blocked in the closed state by a shiftable closer plate provided within the housing at the second end thereof and being shiftable from a first position in which the inlets are blocked to a second position in which the inlets are not blocked.
  • the inlets are blockable by means of individual plugs to be inserted into the inlets for defining the closed state.
  • the mixing of the two constituents for producing the bone cement is preferably carried out while any excessive gas is evacuated from the mixing chamber. Consequently, the apparatus according to the present invention preferably further comprises an evacuation channel communicating with the inner chamber of the housing for evacuating the inner chamber of the housing by means of an external vacuum source.
  • Fig. 1 is an overall perspective and schematic view of a first embodiment of a bone cement mixing apparatus according to the present invention illustrating a first step of mixing a two-constituent bone cement within the apparatus,
  • Fig. 2 is a view similar to the view of Fig. 1 illustrating a second step of mixing the two-constituent bone cement within the apparatus
  • Fig. 3 is a view similar to the views of Figs. 1 and 2 illustrating a third step of mixing the two-constituent bone cement within the apparatus
  • Fig. 4 is a view similar to the views of Figs. 1-3 illustrating a fourth step of mixing the two-constituent bone cement within the apparatus,
  • Fig. 5 is an exploded view of the first embodiment of the bone cement mixing apparatus according to the present invention also illustrated in Figs. 1-4,
  • Fig. 6 is a perspective and schematic view illustrating the first embodiment of the apparatus according to the present invention mounted within a bone cement applicator gun
  • Fig. 7 is an overall perspective, schematic top view of a modified embodiment of the bone cement mixing apparatus according to the present invention
  • Fig. 8 is a view similar to the view of Fig. 7 of a further modified embodiment of the bone cement mixing apparatus according to the present invention.
  • Fig. 9 is an overall perspective and schematic view of a further and presently preferred embodiment of the bone cement mixing apparatus according to the present invention.
  • Fig. 10 is a view similar to the view of Fig. 9 of a twin portion mixing version of the presently preferred embodiment of the bone cement mixing apparatus according to the present invention.
  • components or elements of identical structure and serving the same function in different embodiments are designated the same reference numerals and components or elements of a further embodiment serving the same purpose as a previously described component or element, however, modified in relation to the previously described component or element is designated the same reference numeral, yet added a single or a multiple marking.
  • the expressions “upper” and “lower” refer, unless otherwise indicated, to the orientation of the apparatus during the process of preparing a bone cement mixture, in which instance the apparatus is positioned on a supporting surface such as a table and extends substantially vertically upwards from the supporting surface.
  • a first embodiment of a bone cement mixing apparatus is shown designated the reference numeral 10 in its entirety.
  • the apparatus 10 basically constitutes a combined bone cement mixing apparatus and bone cement applicator apparatus as will be evident from the below description.
  • the apparatus comprises a housing 12 which is composed of a circular-cylindrical wall component 14 defining opposite upper and lower end parts.
  • a closure plug 16 is mounted slidably within the circular- cylindrical wall component 14.
  • the closure plug 16 is, as is evident from Fig. 5, provided with a radial groove in which a sealing O-ring 18 is received.
  • a diametrical bore 20 is provided extending through the lower part of the closure plug 16 below the sealing O-ring 18 serving the purpose of receiving an arresting pin 22 which is mounted extending through opposite bores produced in the wall component 14 opposite the diametrical bore 20 for fixating and arresting the closure plug 16 relative to the wall component 14.
  • the arresting pin 22 is at its one end provided with a reduced diameter part 23 and at its opposite end provided with a handle 24 serving the purpose of allowing a person using the apparatus 10 to remove the arresting pin 22 from its position fixating and arresting the closure plug 16, i.e. from the position illustrated in Fig. 1 after the completion of the bone cement mixing procedure.
  • the annular cylindrical wall component 14 is sealed by a top closure cap 26 which is composed of two parts, a solid body top part 27 and a downwardly protruding annular part 28 having a reduced outer diameter which corresponds to and mates with the inner diameter of the annular cylindrical wall component 14.
  • the top closure cap 26 is sealed to the circular-cylindrical wall component 14 through an adhesive or welded joint as the lower annular part 28 of the top closure cap 26 is received within the annular cylindrical wall component 14.
  • an axial through-going bore 30 extends, and two additional through-going bores 32 and 34 are produced in the solid body top part 27 of the top closure cap 26 as is evident from Fig. 5.
  • the through-going bores 32 and 34 are produced diametrically opposite one another in relation to the axial bore 30.
  • a radially extending fin 36 protrudes from the top surface of the top closure cap 26 .
  • a turnable knob 37 is provided within the axial bore 30, a turnable knob 37 is provided.
  • the knob 37 has a lower annular cylindrical skirt part 38 through which a concentrical through-going bore 39 is produced. Through the outer wall of the annular cylindrical skirt part 38, the turnable knob 37 is received within the through-going axial bore 30 of the top closure cap 26.
  • the component 40 is basically composed of two parts, firstly a tubular top part 42 and a disc-shaped circular part 44.
  • the disc-shaped cylindrical part 44 is provided with two through-going bores 46 and 48 which may be positioned in registration with the through-going bores 32 and 34, respectively, of the top closure part 26.
  • two sealing O-rings 50 and 52 are received for sealing against the lower surface of the solid body part 27 of the top closure cap 26.
  • a further sealing O-ring 54 is received for sealing against the inner surface of the lower annular part 28 of the top closure cap 26.
  • the tubular part 42 extends through the through-going bore 30 of the top closure cap 26 and further into the through-going bore 39 of the turnable knob 37 and is fixated relative to the knob 37.
  • the knob 37 and the component 40 are connected to one another in an angular orientation so as to position the through-going bores 46 and 48 of the disc-shaped circular part 44 away from registration with the through-going bores 32 and 34 of the solid body part 27 of the top closure cap 26, provided the knob 37 is positioned in radial continuation of the radially extending fin 36, whereas the through- going bores 46 and 48 of the disc-shaped circular part 44 of the component 40 are positioned in registration with the through-going bores 32 and 34 of the solid body part 27 of the top closure cap 26, provided the turnable knob 37 is positioned in a specific angular orientation relative to the radially extending fin 36.
  • the bone cement mixing apparatus 10 further comprises a stirring assembly shown in the right-hand part of the exploded view of Fig. 5 and designated the reference numeral 56.
  • the stirring assembly 56 comprises an elongated tubular element 58 defining opposite open ends. At the lower open end of the tubular element 58, a three-bladed plate element 60 is arranged defining three individual blade elements each apertured by a through-going hole 62.
  • the stirring assembly 56 further comprises a rod 64 which during the initial steps of preparing a bone cement mixture by means of the bone cement preparing apparatus 10 is mounted within the elongated tubular element 58 of the stirring assembly 56 for providing a closure at the lower end of the elongated tubular element 58 and sealing off the passage within the interior of the elongated tubular element 58.
  • the rod 64 basically includes a central body portion 66 terminating at the upper end in a handle 68 and terminating at the opposite lower end in a plug part 70 which is composed of two circular disc-shaped elements 71 and 72 which are kept in spaced-apart relationship by a pin element 73.
  • the circular disc-shaped element 72 positioned juxtaposed the central body portion 66 is provided with an outer circumferential recess for receiving a sealing O-ring 69.
  • the stirring assembly 56 is in the assembled state of the apparatus 10 mounted within the interior of the housing 12 extending through the inner through-going passage of the tubular top part 42 of the component 40 as is illustrated in Fig. 1.
  • the apparatus 10 is, as stated above, illustrated in a first step of preparing a bone cement mixture as the apparatus is mounted on a stand 110 in an upright position.
  • the stand 110 basically comprises a circular disc-shaped supporting plate 112 for resting and supporting the apparatus on a supporting surface, such as the surface of a table at which a person, such as a nurse, is to prepare a bone cement mixture by means of the apparatus.
  • a supporting surface such as the surface of a table at which a person, such as a nurse, is to prepare a bone cement mixture by means of the apparatus.
  • annular skirt 114 extends upwardly for receiving and arresting the lower end part of the housing 12 as is seen in Fig. 1.
  • the annular skirt 114 is provided with. longitudinally extending slits for receiving the arresting pin 22 and the reduced diameter part 23 thereof, and at the same time for preventing the housing 12 from turning relative to the stand 110.
  • the tube assembly 74 basically comprises a hose 79 which defines opposite ends, one of which is connected to the connector 75, whereas the opposite end is integrally connected to a receptor 80.
  • the receptor 80 is sealable by means of a closure plug 81.
  • the receptor 80 is configurated or shaped so as to allow a bottle 82 including a liquid constituent of the two-component bone cement mixture to be received and supported within the interior sealed chamber defined within the receptor 80 after the neck of the bottle 82 is broken off as indicated by the reference numeral 62.
  • the closure plug 81 is press- fitted into sealing engagement with the lower open end of the receptor 80.
  • the hose 79 has a length, as is evident from Fig. 1, preventing the receptor 80 from resting on the supporting surface, such as the table on which the apparatus 10 rests supported in the stand 110 so as to present the initially opened or unsealed receptor 80 freely hanging in the hose 89 and presenting the open lower end of the receptor 80 at a height above the supporting surface of the table, allowing the person preparing the bone cement mixture to readily introduce the bottle 82 into the interior of the receptor 80 by simply lifting the bottle 82 into the interior of the receptor 80 and thereupon closing the open lower end of the receptor by means of the plug 81.
  • the other tube assembly 76 comprising a hose 84 similar to the hose 74 is present, however differing from the tube assembly 74 in that the hose 84 has a length substantially exceeding the length of the hose 74 and allowing a receptor 86 of the tube assembly 76 to rest on the supporting surface on which the apparatus 10 is positioned and rests supported by the stand 110.
  • the receptor 86 further differs from the receptor 80 in that the receptor 86 constitutes a foldable or collapsible funnel 86 composed of two opposite triangularly shaped walls 88 and 89 which are joined together along joints 90 and 91 and which are foldable away from one another along folding lines or weakening lines 92 and 93, respectively.
  • the foldable and collapsible funnel 86 is erectable from a collapsed state by means of gripping flaps provided at the outer side surfaces of the triangularly shaped walls 88 and 89 at the weakening or folding lines 92 and 93, respectively, one of which gripping flaps is shown in Fig. 1 and designated the reference numeral 94.
  • the oppositely positioned gripping flap provided at the outer side surface of the triangularly shaped wall 89 is hidden in the illustration of Fig. 1.
  • two adhesive coatings are provided at the upper edges of the foldable and collapsible funnel 86.
  • the joints 90 and 91 interconnecting the triangularly shaped walls 88 and 89 te ⁇ ninate a short distance below the upper edges of the triangularly shaped walls 88 and 89 for presenting freely accessible gripping flaps, one of which is designated the reference numeral 96, of release papers covering the adhesive coatings which are described above and one of which is designated the reference numeral 95.
  • the foldable and collapsible funnel 86 is adapted to receive and seal around a bag 98 containing a powder constituent of the two-component bone cement mixture, which bag is opened by cutting a slit 100 at one corner of the bag 98 by means of a knife or a pair of scissors. After the bag 98 has been opened by cutting the slit 100 and completely opened by removing the cut-off end piece of the bag separated by the slit 100, the bag is introduced into the interior of the foldable and collapsible funnel 86 in the position shown in Fig.
  • the funnel 86 is pressed against the bag 98 for causing the adhesives at the upper edge of the inner sides of the triangularly shaped walls 88 and 89 of the funnel 86 to adhere to the bag 98 for sealing off the interior of the bag 98 from the environment.
  • the bottle 82 as well as the bag 98 are now kept in sealed receptors preventing the liquid and powder constituents of the bottle 82 and the bag 98, respectively, from being spilt or otherwise unintentionally allowed to be liberated into the atmosphere and consequently exposed to the person preparing the bone cement mixture by means of the apparatus 10.
  • the first step of preparing the bone cement mixture by means of the apparatus 10 is now terminated.
  • Fig. 2 which illustrates the next or second step of preparing the bone cement mixture
  • the receptor 80 is raised, allowing the liquid constituent contained within the bottle 82 to flow into the hose 79 of the tube assembly 74 and further into the interior of the apparatus 10, as illustrated by liquid drops 102.
  • the bag 98 is caused to deliver the powder constituent to the interior of the apparatus 10 as the person preparing the bone cement mixture grips the gripping flaps, one of which is shown in solid line in Fig. 2 and designated the reference numeral 94, and brings the gripping flaps apart as illustrated by arrows in Fig.
  • the reference numeral 106 for opening the foldable and collapsible funnel 86 and at the same time mechanically agitating or shaking the bag 98 which is adhered to and sealed off relative to the inner sides of the walls 88 and 89 of the funnel 86.
  • the powder delivered from the bag 98 falls into the interior of the apparatus 10 as illustrated by particulate powder 104.
  • the liquid and powder constituents from which the bone cement mixture is to be prepared has now been transferred from the bottle 82 and the bag 98, respectively, into the interior of the housing 12 of the apparatus 10.
  • the liquid and powder constituents are now to be mixed together, as is illustrated in Fig.
  • hoses 74 and 84 are also shown and arrows 116 and 118 indicate that the hoses 74 and 84 may be used for evacuating the interior of the housing 12 during the process of agitating and mixing the liquid and powder constituents of the two-component bone cement mixture together.
  • evacuation of the interior of the apparatus for mixing the two-constituent bone cement mixture together may in an alternative embodiment 10' illustrated in Fig.
  • the modified housing 12' is provided with a modified top closure cap 26' in which a further through-going bore 124 is produced, in which through-going bore a connector 121 is received for establishing connection to the hose 120 similar to the connection established between the hoses 74 and 84 by means of the connectors 75 and 77, respectively.
  • the evacuation through the hose 120 is schematically illustrated by an arrow 122. In Fig.
  • the modified disc-shaped circular part 44' is further provided with an additional through-going passage or bore 126 which may be positioned in registration with the through-going bore 124 of the top closure cap 26' for establishing communication from the interior of the housing 12' through the hose 120 to an evacuation source, not shown in the drawings.
  • the through-going bores 46 and 48 of the disc-shaped circular part 44' are positioned in communication to the hoses 74 and 84, respectively, through the through- going bores 32 and 34, respectively, of the top closure cap 26' in one and the same position of the disc-shaped part 24' relative to the top closure cap 26' , the through-going bore 126 is not at the same time positioned in registration with the through-going bore 124.
  • the through-going bores 124 and 126 are not at the same time positioned in registration to one another.
  • the through-going bores 124 and 126 are positioned in registration to one another, as illustrated in Fig. 7. the through-going bores 46 and 48 of the disc-shaped circular part 44' are not at the same time positioned in registration with the through- going bores 32 and 34 of the top closure cap 26' .
  • a further modified embodiment 10" of the bone cement mixing apparatus comprising a separate evacuation hose 120' .
  • the evacuation hose 120' for evacuating the interior of the housing 12" as illustrated by the arrow 120' is connected to the housing 12" through a side aperture which extends through the circular cylindrical wall component 14' and in which the connector 121' is received.
  • the through-going bores 32 and 34 of the top closure cap are sealed by means of two plugs 128 and 130, respectively.
  • the connector 121 ' of the hose 120' is removed from the through-going bore extending through the circular cylindrical wall component 14' and the through-going aperture is sealed off by engaging the reduced diameter part 23 of the arresting pin in the through-going bore and breaking off the reduced diameter part 23 from the remaining part of the arresting pin 22.
  • the conversion into the applicator syringe is carried out by turning the knob 37 for sealing off the communication between the through-going bores 32 and 34 of the top closure cap 26 and the through-going bores 46 and 48 of the discshaped circular part 44 and positioning the knob 37 in radial registration with the radially extending fin 36 as is illustrated in Fig. 4.
  • the rod 64 is extracted from the interior of the elongated tubular element 58, as is illustrated in Fig. 4 by an arrow 132, for allowing the bone cement mixture present within the interior of the housing 12 to be expelled through the elongated tubular element 58, serving as an ejector tube.
  • the stirring assembly 56 is also raised to its top position in which the three-bladed plate element 60 is concealed within the interior of the annular part 28 of the top closure cap 26.
  • the apparatus 10 is then introduced into an applicator gun 140, as is illustrated in Fig. 6.
  • the applicator gun 140 is of a basically conventional structure and no detailed discussion of the applicator gun is being presented here, as numerous applicator guns are described in the prior art. A single important feature is, however, to be described, namely the configuration of a front plate 142 of the applicator gun 140, in which front plate a radial recess 144 is provided, which recess is configurated so as to only allow the apparatus 10 to be received within the applicator gun 140 provided the knob 37 and the radially extending fin 36 are positioned in radial alignment, corresponding to a position of the disc-shaped circular part 44 relative to the top closure cap 26, in which position the through-going bores 46 and 48 are not communicating with or positioned in alignment with the through-going bores 32 and 34, respectively, of the top closure cap 26.
  • the arresting pin 22 Prior to introducing the apparatus 10 into the applicator gun 140, the arresting pin 22 is also removed, allowing the closure plug 16 to serve as a piston body which is forced into the inner chamber of the housing 12 for expelling the bone cement mixture from the apparatus through the elongated tubular element 58 serving as an ejector tube.
  • FIG. 9 a further and presently preferred embodiment of the apparatus according to the present invention is shown designated the reference numeral 10' " in its entirety.
  • the apparatus 10' " is of an overall structure similar to the structure of the above described apparatus 10 illustrated in Figs. 1-6, however, differing from the apparatus 10 in that the apparatus 10'" is of a more simple structure in which the rotatable disc-shaped circular part 44 is omitted.
  • plugs 128' and 130' similar to the plugs 128 and 130 described above with reference to Fig. 8, which plugs 128' and 130' are connected or linked to the top closure cap 26" through connecting bands 129 and 131, respectively, preventing the plugs 128' and 130' from being dispositioned or lost.
  • the apparatus 10' " illustrated in Fig. 9 is furthermore defined through the provision of a linking band 132 by means of which the closure plug 81' is connected to the receptor 82' .
  • the connectors 75' and 77' of the tube assemblies 74' and 76' are provided with closure plugs 133 and 135, respectively which are linked to the connectors 75' and 77' , respectively, through linking bands 137 and 141, respectively.
  • a further modification of the above described presently preferred embodiment of the apparatus 10' ' ' is shown, in which modification the tube assemblies 74' ' and 76' ' are provided with Y- branchings as the tube assembly 74' ' comprises two identical receptors 80' for receiving two individual bottles 82, each containing one portion of the liquid constituent of the bone cement mixture.
  • the tube assembly 76" comprises two foldable and collapsible funnels 86' for receiving a total of two bags, each containing a portion of the powder constituent of the bone cement mixture.
  • the modified apparatus 10' " illustrated in Fig. 10 consequently allows the mixing of a bone cement mixture twice as big as the portion prepared from a single bottle 82 and a single bag 98 as described above with reference to Figs. 1-9.
  • a prototype embodiment of the presently preferred embodiment of the apparatus according to the present invention 10' " illustrated in Fig. 9 was made from the following components.
  • the circular cylindrical wall component 14 was made from a length of 220 mm of a tube made from Nylon 11 having an inner diameter of 38 mm and an outer diameter of 42 mm.
  • the top closure cap 26 was machined from Nylon 11 defining an outer diameter of 46 mm.
  • a lower circumferential recess was machined in the top closure cap 26 for allowing the top closure cap to be highfrequency welded to the circular-cylindrical wall component 14.
  • the elongated tubular element 58 of the stirring assembly 56 was made from a length of 270 mm tube of Nylon 11, the inner diameter of the tube being 10 mm and the outer diameter of the tube being 12 mm.
  • the three-bladed plate element 60 was also made from Nylon 11.
  • the rod 64 defined an overall length of 300 mm and was assembled from individual components made of Nylon 11 which were glued and welded together in the structure illustrated in Figs. 1, 5 and 9.
  • the sealing O-ring 69 was a conventional rubber sealing ring.
  • the hose 79 and the hose 89 of the tube assemblies 74' and 76', respectively, were both made from PVC hoses, and the hose 76 had an overall length of 250 mm and the hose 89 had an overall length of 540 mm.
  • the receptor 80' was made from a Nylon 11 container defining an overall length of 100 mm, an outer diameter of 25,5 mm and an inner diameter of 22,5 mm, and the closure plug 81 ' was also made from Nylon 11.
  • the collapsible funnel 86 was made from foil material which was adhered to the outer free end of the hose 89 by means of an adhesive.
  • the triangularly shaped walls 88 and 90 were made from PVC foil, each measuring at their widest opening 195 mm and a distance to the vertex of the triangle from the free top edges of the triangle measuring 100 mm.
  • the connectors 75' and 77' were produced from Nylon 11.
  • the stand 110 was an aluminum stand.
  • the arresting pin 22 was a Nylon 11 plug of the configuration illustrated in Fig. 5 and defining a total length of 70 mm.
  • the apparatus may for some applications be modified into an apparatus for mixing more than two constituents, such as three or more constituents, and the ejector tube constituted by the elongated tubular element 58 may be substituted by separate tubular elements connectable to the top closure cap through a junction, which junction is offset relative to the longitudinal axis of the housing 12.
  • the stirring assembly 56 may similarly be modified by closing off the lower end of the tubular element 58 or simply substituting the tubular element 58 with a solid rod.

Abstract

L'invention porte sur un appareil pour la préparation de ciment osseux à partir de deux constituants ou plus, contenus dans leurs récipients fermés respectifs, comportant: une enceinte présentant une première extrémité ouverte et une deuxième extrémité fermée opposée; un piston placé dans une chambre comprise dans l'enceinte; au moins deux ensembles récepteurs communiquant avec la chambre par leurs orifices d'introduction respectifs commutables entre une position d'ouverture où s'établit une communication entre les récepteurs et la chambre, et une position de fermeture où la communication est fermée. Chacun des ensembles récepteurs comporte un récepteur recevant son propre récipient fermé d'où part un passage étanche le reliant à l'intérieur de la chambre. L'appareil comprend de plus un malaxeur placé dans l'enceinte et s'y déplaçant, et commandé depuis l'extérieur, et un tube éjecteur relié à la deuxième extrémité de l'enceinte mobile entre une première position et une deuxième position; dans la première position la communication entre la chambre et le tube éjecteur est bloquée, et dans la deuxième position, ledit tube met en communication l'enceinte avec l'environnement.
PCT/DK1998/000208 1997-05-21 1998-05-22 Appareil pour la preparation de ciment osseux WO1999067015A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU74255/98A AU7425598A (en) 1997-05-21 1998-05-22 An apparatus for preparing bone cement
EP98921372A EP1035909A1 (fr) 1997-05-21 1998-05-22 Appareil pour la preparation de ciment osseux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK58497 1997-05-21
DK0584/97 1997-05-21

Publications (1)

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WO1999067015A1 true WO1999067015A1 (fr) 1999-12-29

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EP (1) EP1035909A1 (fr)
AU (1) AU7425598A (fr)
WO (1) WO1999067015A1 (fr)

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US6796701B2 (en) * 2000-02-28 2004-09-28 Coripharm Medizinprodukte Gmbh & Co. Kg Preparation and application device for implant materials with hand-operated pump
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US7073936B1 (en) 1993-05-10 2006-07-11 Cemvac System Ab Method and device for feeding components for bone cement into a mixing vessel
US6874927B2 (en) * 2000-01-31 2005-04-05 Summit Medical Limited Orthopaedic cement mixing and dispensing device
US6796701B2 (en) * 2000-02-28 2004-09-28 Coripharm Medizinprodukte Gmbh & Co. Kg Preparation and application device for implant materials with hand-operated pump
US7160020B2 (en) * 2000-10-25 2007-01-09 Kyphon Inc. Methods for mixing and transferring flowable materials
US7278778B2 (en) 2000-10-25 2007-10-09 Kyphon Inc. System for mixing and transferring flowable materials
US6648499B2 (en) 2001-06-14 2003-11-18 Cemvac System Ab Method and device for extruding bone cement under vacuum
WO2002102286A1 (fr) * 2001-06-14 2002-12-27 Cemvac System Ab Methode et dispositif destines a la preparation de ciment osseux
US6974247B2 (en) * 2002-04-11 2005-12-13 Synthes (U.S.A.) Device for mixing and/or injecting cements
US7168847B2 (en) * 2002-04-11 2007-01-30 Synthes (Usa) Device for mixing and/or injecting cements
WO2004032808A3 (fr) * 2002-10-04 2004-08-19 Baxter Int Dispositifs et procedes pour le melange et l'extrusion de compositions utiles a usage medical
US8061887B2 (en) 2003-05-12 2011-11-22 Stryker Corporation Cartridge in which bone cement is mixed and from which bone cement is delivered, the cartridge having a compressible blade with plural vanes
US7841763B2 (en) * 2004-03-08 2010-11-30 Summit Medical Limited Bone cement mixer with a discharge valve attached to the support base
US7594578B2 (en) 2005-01-26 2009-09-29 Biomet Manufacturing Corp. Method and apparatus for storing bone cement components
EP1685812A3 (fr) * 2005-01-26 2006-09-06 Biomet Manufacturing Corp. Procédé et dispositif servant à conserver des constituants de ciment osseux
US8075176B1 (en) * 2006-11-13 2011-12-13 Luis Cordero Hand held manually operated mixer
US9999459B2 (en) 2009-03-17 2018-06-19 Stryker European Holdings I, Llc Vacuum mixing device for bone cement and method for mixing bone cement in said device
US9186635B2 (en) 2009-03-17 2015-11-17 Stryker Ireland Limited Vacuum mixing device for bone cement and method for mixing bone cement in said device
EP2269718A2 (fr) 2009-06-29 2011-01-05 Heraeus Medical GmbH Dispositif de mélange et d'extraction de ciment osseux
DE102009031178B3 (de) * 2009-06-29 2010-09-16 Heraeus Medical Gmbh Vorrichtung zum Mischen und Austragen von Knochenzement
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