EP1738744B1 - Skin-friendly insect repellent - Google Patents

Abstract

A cosmetic composition comprises one or more repellent active agents with a vapor pressure of at least 3.2 x 10 -4> hPa at 20[deg]C and one or more substances with a log P value of -2.5 to 2.5. Independent claims are included for: (1) a packaging agent, obtained from polyethylene, polypropylene or polyethylene terephthalate comprising the cosmetic composition; and (2) a band-aid or cloth immersed in the cosmetic composition.

Description

The present invention relates to a cosmetic preparation comprising one or more repellent active ingredients having a vapor pressure of at least 3.2 10 ^-4 hPa at 20 ° C. and one or more substances having a log P value of from -2.5 to +2, 5th

Insect repellents (insect repellents, insect repellents, repellents, repellents) are preparations that are used externally to repel and / or expel insects, as well as ticks and mites, and to prevent them from becoming active on the skin. Insect repellents are intended to protect the skin from nuisance by blood sucking or biting insects and other parasites and / or pests by repelling them before settling on the skin. Accordingly, the agents do not act as contact poisons, but only as a repellent, as they do not kill the animals, but merely drive them away.

Accordingly, for the purposes of the present invention, the term "insect repellent" is to be understood not only those preparations which are effective against insects (especially mosquitoes). Rather, it will be understood that what has been said below also applies to such preparations which repel or expel other blood-sucking or biting parasites and / or pests (e.g., spiders, fleas, mites), though this may not be mentioned on a case-by-case basis.

Since time immemorial people are plagued by stinging or biting insects or other parasites. Accordingly old is the need of humanity for insect repellents. A method known from early history to make annoying or harmful insects their stay near the man unattractive or unpleasant is the lighting of fires with aromatic or strongly smelling herbs or woods and heavy smoke. Even the treatment of the skin with strong-smelling substances to repel insects has been known since ancient times. At the turn of the last century, a number of natural essential oils were in use as insect repellents, such as aniseed oil, bergamot oil, birchwood tar, camphor oil, citronella oil, eucalyptus oil, geranium oil, pine oils, coconut oil, lavender oil, nutmeg oil, clove oil, orange blossom oil, peppermint oil, pollen oil (pennyroyal oil), Pyrethrum, thyme oil and cinnamon oil.

Because of their insufficient despite intense odor efficacy and their sometimes lacking compatibility in higher concentrations, these substances have been largely replaced in today's insect repellent by better-acting synthetic substances. These are predominantly high-boiling liquids or low-melting or subliming crystalline substances which slowly evaporate at room temperature. Most repellent agents belong to the classes of amides, alcohols, esters and ethers.

und einen bei 20 °C einen Dampfdruck von 3,4 10^-4 hPa aufweist. 1-Piperidincarboxylsäure 2-(2-hydroxyethyl)-1-methylpropylester gilt als besonders wirksamer Repelient-Wirkstoff. Insektenabwehrmittel des Standes der Technik, die mit 1-Piperidincarboxylsäure 2-(2-hydroxyethyl)-1-methylpropylester formuliert werden, weisen jedoch eine Reihe von Nachteilen auf. Insbesondere bei Zubereitungen, die gegen Zecken oder die aggressive Anopheles-Mücke wirken sollen, muss der Wirkstoff in hohen Konzentrationen (bis zu 20 Gewichts-% der Zubereitung) eingesetzt werden, um bei der Anwendung eine begrenzte Zeit ausreichend wirksam zu sein. Die Zubereitungen des Standes der Technik haben bei derartig hohen Einsatzkonzentrationen den Nachteil, insbesondere bei Menschen mit empfindlicher oder zu Allergien neigender Haut nicht besonders verträglich zu sein und in Einzelfällen zu Hautreizungen zu führen.A modern repellent active ingredient is, for example, the 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester (INN: icaridine, CAS number: 119515-38-7, Elincs number: 423-210-8), which is the following structure

and at 20 ° C has a vapor pressure of 3.4 10 ^-4 hPa. 1-Piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester is considered to be a particularly effective repelient agent. However, prior art insect repellants formulated with 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester have a number of disadvantages. In particular, in preparations which are to act against ticks or the aggressive Anopheles mosquito, the active ingredient must be used in high concentrations (up to 20% by weight of the preparation) in order to be sufficiently effective in use for a limited time. The preparations of the prior art have at such high use concentrations the disadvantage, especially in people with sensitive or prone to allergies skin not to be particularly compatible and to lead in some cases to skin irritation.

It was therefore the object of the present invention to develop cosmetic preparations containing 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester, which are particularly skin-friendly and hypoallergenic, and have a reduced skin irritation potential.

• a) 1-Piperidincarboxylsäure 2-(2-hydroxyethyl)-1-methylpropylester (INN: Icaridin) und
• b) eine oder mehrere Substanzen mit einem log P-Wert von -2,5 bis +2,5, gewählt aus der Gruppe mehrwertige Alkohole, lineare Alkohole, verzweigte Alkohole, C5-C10 Alkylalkohole, Polyglycerine.

The object is surprisingly achieved by a high-density polyethylene (HDPE) packaging containing a cosmetic preparation

• a) 1-Piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester (INN: icaridin) and
• b) one or more substances having a log P value from -2.5 to +2.5, selected from the group of polyhydric alcohols, linear alcohols, branched alcohols, C5-C10 alkyl alcohols, polyglycerols.

Although knows the state of the art DE 103 49 666 A1 . WO 03/020232 . WO 02/43490 , WO 02/43656 , but these writings could not point the way to the present invention.

• Der Verteilungskoeffzient Log P ist der Quotient der Konzentrationen einer Substanz in der Wasserphase bzw. der Octanolphase nach Einstellung des Verteilungsgleichgewichtes. Die analytische Bestimmung der Konzentrationen wird meist UV-spektroskopisch durchgeführt.
• Der Octanol//Wasser-Verteilungskoeffizient (P) einer Substanz "A" ist definiert als
  (Gleichung 1): $$\mathrm{P}\mathrm{=}\frac{\mathrm{Konzentration}\mathrm{-}\mathrm{Lipidphase}}{\mathrm{Konzentration}\mathrm{-}\mathrm{Wasserphase}}\mathrm{=}\mathrm{>}\mathrm{log\; P}\mathrm{=}\log \frac{\left[\mathrm{Octanol}\right]}{\left[\mathrm{Wasser}\right]}$$
  
  
  Log P > 0 => Substanz löst sich besser in Octanol
  Log P <0 => Substanz löst sich besser in Wasser

Whether a substance has a log P value of -2.5 to +2.5 can be determined according to the invention using the following measurement method:

• The distribution coefficient Log P is the quotient of the concentrations of a substance in the water phase or the octanol phase after adjustment of the distribution equilibrium. The analytical determination of the concentrations is usually carried out by UV spectroscopy.
• The octanol // water partition coefficient (P) of a substance "A" is defined as
  (Equation 1): $$\mathrm{P}\mathrm{=}\frac{\mathrm{concentration}\mathrm{-}\mathrm{lipid\; phase}}{\mathrm{concentration}\mathrm{-}\mathrm{water\; phase}}\mathrm{=}\mathrm{>}\mathrm{log\; P}\mathrm{=}\log \frac{\left[\mathrm{octanol}\right]}{\left[\mathrm{water}\right]}$$
  
  
  Log P> 0 => Substance dissolves better in octanol
  Log P <0 => Substance dissolves better in water

E₀ = Extinktion Maßlösung: E₁ = Extinktion der Probe in Wasser ( Maßlösung in Wasser)It is also possible to directly insert the extinctions of the UV spectroscopic concentration determination into the equation. At a octanol / water 1/1 volume ratio (Equation 2): $$\mathrm{Log\; P}\mathrm{=}\log \frac{{\mathrm{e}}_{\mathrm{0}}\mathrm{-}{\mathrm{e}}_{\mathrm{1}}}{{\mathrm{e}}_{\mathrm{1}}}$$

E ₀ = extinction standard solution: E ₁ = absorbance of the sample in water (standard solution in water)

Test Description:

Equipment: standard solution (20-100 ml), DC (small), DC plate aluminum grinder, 5 funnel, clamp, tripod ring, centrifuge, centrifuge tubes, UV spectrometer, quartz cuvettes (1 cm).
Chemicals: octanol, dist. Water, substance

The resulting sample is examined for purity by means of thin-layer chromatography, since even slight impurities have a strong effect on the extinction and thus on the extinction-determined Log P value.

A standard solution (usually 10 ^-4 M) is then prepared in the respective buffer (volumetric flask), which is used in the shaking experiment as well as the standard for the UV measurement

A UV spectrum of the standard solution is recorded (200nm - 300nm scan mode).

The standard solution should have an absorbance of between 0.25 and 1.0 at maximum.

If this is not the case, dilute accordingly.

15 ml of the standard solution are filled with 15 ml of the appropriate, missing solvent in a separatory funnel (volume ratio organic phase / aqueous phase, 1/1) and 15 - 20 min. shaken evenly. To complete the phase separation is centrifuged at 2500-3000 rpm for 20 min.

Alternatively, shake the sample in 2 ml eppendorf caps. For this purpose, 1 ml of the standard solution and 1 ml of the missing solvent for 15 - 20 min. in a '2ml-eppi' mixed in a special shaker, the separation of the two phases is completed by centrifugation.

A third option - and also the method of choice - offers a special shaking apparatus. Here can be clamped with each 2 (3) ml of octanol and water (or buffer) filled closable centrifuge tubes and for at least 20 min. be shaken. Thereafter, the centrifugation step described above follows again.

During the centrifugation, the standard solution is again measured against the corresponding solvent by UV spectroscopy (value = E ₀ ). After completion of the centrifugation equal amounts (volume) are removed from the water or octanol phase and measured against the corresponding solvent by UV spectroscopy. The extinctions obtained can be used directly to determine the distribution coefficient (see equation (2)).

In addition, the log P value can be calculated by the method of "Hansch and Leo" published in 1979.

The Hansch and Leo methods include deduced fragment constants f (atoms or atomic groups) and structure factors F (take into account the spatial arrangement of the molecule The calculation of the distribution constant log Kow follows the equation: $$\mathrm{log\; K}=\mathrm{\Sigma \; F}+\mathrm{\Sigma \; f}$$

The f and F values were derived from hundreds of known compounds. With the fragment values f it must be distinguished whether they are bound to aliphatic or aromatic C atoms. In addition, another 14 structural parameters that provide information on molecular mobility must be considered.

literature

• Seydel, Schaper, Chemical structure and biological activity of active ingredients, 1979, Verlag: Chemie Weinheim
• Strategy of Drug Design: A Guide to Biological Activity, Purcell, Bass, Clayton, 1973, J. Wiley and Sons
• Rekker, Mannhold, Calculation of Drug Lipophilicity, 1992, Verlag Chemie Weinheim
• Kubiny, H .; QSAR: Hansch Analyzes and Related Approaches, Vol. 1, chap. 4.5 , 5. 77 ff Brehm, O., Ohlmeyer, I. and Fels, G .; Automated pKa and logP determination. GIT Laboratory Journal, 1997, 41, 368-374 ,

It is advantageous for the purposes of the present invention, when the Zuberitung invention is characterized in that the cosmetic preparation repellent active ingredients with a vapor pressure of at least the cosmetic preparation repellent agents having a vapor pressure of at least 3.2 10 ^-4 hPa at 20 ° C in a total concentration of 1 to 40% by weight and preferably in a total concentration of 10 to 20% by weight, based in each case on the total weight of the preparation.

Furthermore, it is advantageous for the purposes of the present invention, when the preparation according to the invention is characterized in that the cosmetic preparation substances having a log P value of -2.5 to +2.5 in a total concentration of 0.1 to 20 weight -% and preferably in one Total concentration of 1 to 10% by weight, based in each case on the total weight of the preparation contains.

Advantageous embodiments of the present invention are characterized in that the preparation according to the invention, characterized in that the weight ratio of the total amount of repellent agents having a vapor pressure of at least 3.2 ˙ 10 ^-4 hPa at 20 ° C to the total amount of substances with a log P value of -2.5 to + 2.5 from 20: 1 to 1: 1 and preferably from 10: 1 to 2: 1.

It is in accordance with the invention if 2- (2-hydroxyethyl) -1-methylpropyl ester (INN: icaridine) is used as the repellent Vfirkston with a vapor pressure of at least 3.2 10 ^-4 hPa at 20 ° C. 1-piperidinecarboxylic acid.

It is in accordance with the invention if one or more compounds selected from the group consisting of polyhydric alcohols, linear alcohols, branched alcohols, C 5 -C 10 -alkyl alcohols, polyglycerols are used as substances having a log P value of from about 2.5 to about 2.5.

It is preferred according to the invention if one or more compounds selected from the group C5-C10 alkyl alcohols and branched alcohols are used as substances having a log P value of from about 2.5 to about 2.5.

Particularly preferred according to the invention is the use of C5-C10 alkyl alcohols as substance with a log P value of -2.5 to +2.5.

erfindungsgemäß bevorzugt, wenn die kosmetische Zubereitung in Form einer Emulsion vorliegt.According to the invention, the cosmetic preparation according to the invention is advantageously characterized in that the preparation is in the form of an aqueous or aqueous-alcoholic solution, an emulsion (W / O, OIW, W / S, S / W or multiple emulsion), a dispersion, a Pickering® Emulsion is present. That's it

preferred according to the invention if the cosmetic preparation is in the form of an emulsion.

According to the invention, the preparation may advantageously be present in the form of a low-viscosity, sprayable aqueous or aqueous-alcoholic solution, in the form of a gel, as an ointment, cream or lotion (if desired sprayable).

According to the invention, the preparation can advantageously also be used as a spray or as a soaking medium for a plaster or cloth. Therefore, plasters and wipes are impregnated with the preparation according to the invention, according to the invention.

The aqueous phase of the preparations according to the invention may advantageously contain customary cosmetic auxiliaries, for example alcohols, in particular those of low C number, preferably ethanol and / or isopropanol, diols or polyols of low C number and their ethers, preferably propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, polymers, foam stabilizers, electrolytes, self-tanning agents, and in particular one or more thickening agents, which may be advantageously selected from the group of silicon dioxide, aluminum silicates, Polysaccharides or their derivatives, for. As hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.

Any oil phase present may contain all conventional ingredients of oil, fat and wax components used in cosmetics.

As emulsifiers, it is possible to use all emulsifiers and emulsifier systems known from cosmetics.

In addition to the repellent active ingredients according to the invention, the preparation according to the invention may contain other cosmetic active ingredients and care substances, for example the UV light protection filters authorized according to the Cosmetics Ordinance, and preservatives or preserving aids. According to the invention, such active ingredients may advantageously be present in concentrations of 0.01 to 30% by weight, based on the total weight of the preparation in this.

In particular, niacinamide, panthenol, aloe vera, Hammamelis extract, polidocanol, vitamin E, vitamin E derivatives, vitamin A, vitamin A derivatives, vitamin C, vitamin C derivatives, coenzyme Q10, creatine, taurine, alphaglycosylrutin can be used as further care substances and / or in concentrations of 0.1 to 30% by weight, based on the total weight of the preparation.

According to the invention, the preparation according to the invention particularly preferably contains alpha-hydroxy acids and / or salts thereof as further constituents. Lactic acid / lactates or citric acid / citrates are preferably used according to the invention in a concentration of 0.01% to 5% by weight, based on the total weight of the preparation.

It is advantageous according to the invention if the cosmetic preparation according to the invention is free from parabens.

The packaging according to the invention is advantageously present in the form of a tube or a plastic bottle. Plastic bottles are inventively preferred. An embodiment which is particularly preferred according to the invention represents plastic bottles with an attached pump dispenser with which the preparation according to the invention can be conveyed from the packaging material and, if necessary, sprayed.

According to the invention, the use of "high density polyethylene" i. High density polyethylene (HDPE according to DIN 7728, Tl. 1, 01/1988).

In particular, according to the invention, the use of the preparation according to the invention for the prevention of mosquito bites and tick bites.

The following examples are intended to illustrate the present invention without limiting it. The information always refers to weight%, unless otherwise stated. <B><u> W / O emulsions </ u></b> 1 2 3 4 5 Triglycerindiisostearat 1.0 0.5 0.25 2.0 3.0 Diglycerindipolyhydroxystearat 1.0 1.5 1.75 3.0 2.0 paraffin oil 12.5 10.0 8.0 5.0 7.5 vaseline 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1.0 2.5 5.0 0.25 oleate 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 aluminum stearate 0.4 0.3 0.6 1.0 0.05 dicaprylyl 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0 methyl propanediol 0.5 1.0 --- 0.25 2.5 magnesium sulfate 0.5 0.6 0.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.2 0.3 1.0 sodium citrate 0.2 12:05 0.4 0.3 2.0 Perfume q, s, q, s, q, s, q, s, q, s, ethanol 2.0 --- 5.0 --- --- Caprylic / capric 2.0 2.5 3.0 5.0 0.5 potassium sorbate 0.04 0.15 0.05 0.03 0.4 benzyl alcohol 0.3 0.4 0.25 0.15 --- Pentylene glycol --- --- 1.5 --- --- Icaridin 5 7.5 10 12.5 30 water ad 100 ad 100 ad 100 ad 100 ad 100 6 7 8th 9 10 PEG-30 dipolyhydroxystearate --- 0.5 0.25 --- 8.0 Lanolin Alcohol 1.0 1.5 1.75 3.0 - paraffin oil 12.5 10.0 8.0 5.0 12.5 vaseline 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1.0 2.5 5.0 0.25 Hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 aluminum stearate 0.4 0.3 0.6 1.0 0.05 dicaprylyl 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0 Microcrystalline cellulose 0.5 1.0 0.75 0.25 0.1 magnesium sulfate 0.5 0.6 0.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.2 0.3 1.0 Perfume q, s, q, s, q, s, q, s, q, s, 1,3 butylene glycol 2.0 --- 5.0 --- --- Caprylic / capric 2.0 2.5 3.0 5.0 0.5 Natriumdehydracet --- --- 0.05 --- --- potassium sorbate 0.3 0.4 0.25 0.15 --- polyurethane 1.5 --- 1.0 2.5 10 Icaridin 7.5 12.5 17.5 20 35 methyl propanediol 1.5 3.5 1.75 4 3.5 water ad 100 ad 100 ad 100 ad 100 ad 100 11 12 13 14 15 Cetyl PEG / PPG-10/1 dimethicone 1.0 --- - 3.0 5.0 Cylomethicone + PEG / PPG-18/18 dimethicone (90:10) 10.0 12.5 25 - - cyclomethicone 12.5 15 28.0 25.0 17.5 dimethicone 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 panthenol 0.5 1.0 0.75 0.25 0.1 sodium chloride 2.0 0.6 2.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.2 0.3 1.0 sodium citrate 1.0 0.1 0.4 0.9 2.5 Perfume q, s, q, s, q, s, q, s, q, s, potassium sorbate 0.4 0.1 0.05 0.3 0.4 cetyidimethicone 0.5 --- 0.7 --- --- benzyl alcohol --- --- 0.05 --- 0.1 pentaerythritol 0.3 6 1.25 2.0 7.5 Icaridin 3 15 12.5 20 7.5 water ad 100 ad 100 ad 100 ad 100 ad 100 16 17 18 19 20 Cetyl PEG / PPG-10/1 dimethicone 1.0 --- - 3.0 5.0 Cylomethicone + PEG / PPG-18/18 dimethicone (90:10) 10.0 12.5 25 - - cyclomethicone 12.5 15 28.0 25.0 17.5 dimethicone 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 panthenol 0.5 1.0 0.75 0.25 0.1 sodium chloride 2.0 0.6 2.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 lactic acid 0.2 0.1 0.2 --- --- sodium lactate 0.2 1.0 12:05 --- --- Perfume q, s, q, s, q, s, q, s, q, s, Icaridin 3.0 10 12.5 15 30 stearyl 0.5 --- 0.7 --- --- potassium sorbate --- --- 0.05 --- 0.1 Caprylyl glycol 0.3 2.0 12.5 1.5 3 water ad 100 ad 100 ad 100 ad 100 ad 100 21 22 23 24 25 PEG-22 dodecyl glycol copolymer 5.0 1.5 0.25 --- 3.0 PEG-45 dodecyl glycol polymer 1.0 1.5 1.75 3.0 - paraffin oil 12.5 10.0 8.0 5.0 17.5 isopropyl 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1.0 2.5 5.0 0.25 Evening primrose oil 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 aluminum stearate 0.4 0.3 0.6 1.0 0.05 dicaprylyl 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0 hexanediol 0.5 4 1.5 2.0 10 Icaridin 5 10 15 20 25 magnesium sulfate 0.5 0.6 0.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 sodium citrate 0.2 0.1 --- --- --- citric acid 0.2 0.1 --- --- --- Perfume q, s, q, s, q, s, q, s, q, s, 1,3 butylene glycol 2.0 --- 5.0 --- --- Caprylic / capric 2.0 2.5 3.0 5.0 0.5 potassium sorbate 0.4 0.15 0.05 0.3 0.4 benzyl alcohol --- --- 0.05 --- 0.1 water ad 100 ad 100 ad 100 ad 100 ad 100 26 27 28 29 30 Polyglyceryl-2 dipolyhydroxystearate 3.0 --- 0.25 --- 6.0 Polyglyceryl-3 diisostearate 1.0 3.5 1.75 2.5 - PEG-40 sorbitan isostearate --- 2.5 0.5 3.5 3.0 paraffin oil 12.5 10.0 8.0 5.0 17.5 isopropyl 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1.0 2.5 5.0 0.25 isopropyl palmitate 0.5 1.0 0.75 3.0 0.25 dicaprylyl 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0 Ethylhexylglycerin 1,618 1,618 0.75 1.5 4 Icaridin 1,618 16.18 7.5 15 40 magnesium sulfate 0.5 0.6 0.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.1 0.3 1.0 sodium citrate 0.2 0.3 0.2 1.5 0.8 Perfume q, s, q, s, q, s, q, s, q, s, Caprylic / capric 2.0 2.5 3.0 5.0 0.5 potassium sorbate 0.24 0.15 0.05 0.3 0.4 water ad 100 ad 100 ad 100 ad 100 ad 100 31 32 33 34 35 Dimethicone copolyol, caprylic / capric triglyceride 1.0 2.0 8.0 3.0 5.0 cyclomethicone 12.5 15 25.0 10.0 7.5 dimethicone 5.0 15.0 5.0 12.0 15.0 mineral oil 0.5 0.75 1.0 2.0 0.25 Phenyl 0.5 1.0 0.75 3.0 0.25 glycerin 5.0 7.5 10.0 3.0 1.0 Decylene glycol 1 4 8th 4 1.5 Icaridin 10 20 30 40 15 Xanthan gum --- 0.1 - 0.25 1.0 panthenol 0.5 1.0 0.75 0.25 0.1 Perfume q, s, q, s, q, s, q, s, q, s, methylparaben 0.4 0.1 0.05 0.3 0.4 Propylparaben 0.3 0.4 0.25 0.15 --- iodopropynylbutylcarbamate --- --- 0.05 --- 0.1 water ad 100 ad 100 ad 100 ad 100 ad 100 36 37 38 39 40 Glycerylsterat 1.0 --- - 0.5 0.75 Polyethylene glycol (40) stearate 10.0 --- 5 - - Triglycerinmethylglucosedistearat --- 5.5 --- --- 3.5 sorbitan --- 1.5 3 --- --- cyclomethicone 2.5 15 8.0 5.0 7.5 dimethicone 5.0 3.0 5.0 2.0 5.0 behenyl 1 --- 2 1 --- stearyl --- 1 --- 1 --- Ginkgo Biloba 0.1 0.5 1.0 2.5 1.0 Icaridin 7.5 15 12.5 20 25 Cetylstearylalkohol --- --- 1 1 --- hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 Perfume q, s, q, s, q, s, q, s, q, s, methylparaben 0.4 0.1 0.05 0.3 0.4 Propylparaben 0.3 0.4 0.25 0.15 --- iodopropynyl butylcarbamate --- --- 0.05 --- 0.1 methyl propanediol 0.75 1.5 5 2.0 10 water ad 100 ad 100 ad 100 ad 100 ad 100 41 42 43 44 45 Polyethylene glycol (21) stearyl ether 1 - 2.5 2 1.5 Polyethylene glycol (2) stearyl ether 1 - 5.5 3 7.5 cetearylglucoside --- 8th --- --- --- behenyl 3 2 --- 1 --- stearyl 3 2 --- 2 --- Cetylstearylalkohol 3 4 --- --- 2 hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 Icaridin 10 20 15 7.5 5.0 octyldodecanol 0.5 1.0 0.75 3.0 0.25 methyl propanediol 5 1.0 1.5 3 7.5 panthenol 0.5 1.0 0.75 0.25 0.1 Perfume q, s, q, s, q, s, q, s, q, s, methylparaben 0.4 0.1 0.05 0.3 0.4 Propylparaben 0.3 0.4 0.25 0.15 --- iodopropynyl butylcarbamate --- --- 0.05 --- 0.1 Neopentyl glycol 1 2 1.5 3 0.5 water ad 100 ad 100 ad 100 ad 100 ad 100 46 47 48 49 50 Glycerylsteratcitrat 1.0 0.5 1.5 9.0 0.3 Polyethylene glycol (20) cetearylether 10.0 1.0 5 - - Triglycerinmethylglucosedistearat --- --- 3.5 --- 2.5 Trimethylopropane 0.75 1.5 2.25 12 3.75 Icaridin 7.5 15 22.5 30 37.5 dimethicone 0.5 3.0 0.75 1.5 0.2 behenyl 1 --- 2 --- 0.2 dicaprylyl 3 5 10 5 5 stearyl --- --- --- 1 0.2 Cetylstearylalkohol --- --- 1 1 0.2 tocopherol 0.5 0.5 0.75 0.25 0.1 octyldodecanol 0.5 --- 0.75 3.0 0.25 panthenol 0.5 --- 0.75 0.25 0.1 Carbomer 0.05 0.35 0.15 0.1 --- Perfume q, s, q, s, q, s, q, s, q, s, Caprylic / Capric triglyceride 1 5 3 5 10 methylparaben 0.4 0.3 0.05 0.3 0.4 Propylparaben 0.3 --- 0.25 0.15 --- iodopropynyl butylcarbamate --- --- 0.05 --- 0.1 phenoxyethanol --- 0.5 --- 0.15 --- sorbitol 10 --- - 5 --- butylene --- --- --- 5 10 propylene glycol --- --- 10 5 --- glycerin --- 7.5 --- --- --- water ad 100 ad 100 ad 100 ad 100 ad 100 51 52 53 54 55 Glycerylsterat 2.6 --- --- 2.7 2.6 Caprylic / Capric triglyceride 3.5 4.0 3.75 3.1 5.5 dicaprylyl 3.5 2.5 3.75 --- 3.0 Triglycerinmethylglucosedistearat --- 3.0 3.0 --- --- Cetystearylalkohol 3.0 --- --- 4.0 3.5 dimethicone --- 3.0 5.0 3.0 2.75 cetyl alcohol --- 3.0 1.5 1.25 --- Polyethylene glycol (40) stearate 0.8 --- --- 1.3 1.3 C12-15 alkyl benzoate --- 2.5 3.75 3.0 4.5 Buthylethylpropandiol 0.5 1.0 1.5 4 2.5 Icaridin 5 10 15 20 25 Natriumoleanolat 0.1 0.1 0.1 0,075 0.1 cyclomethicone 3.5 --- --- --- 0.25 propylene glycol 0.5 0.5 0.5 0.35 0.2 mineral oil --- --- --- 6.0 --- phenoxyethanol 0.4 0.4 0.4 0.75 1.25 citric acid --- --- 0.05 --- --- ethanol --- --- --- 3.0 --- Ethylparaben --- --- --- 0.3 --- methylparaben 0.2 0.2 0.2 0.2 0.2 glycerin 10.0 10.0 10.0 10.0 12.5 Propylparaben 0.1 0.1 0.1 0.1 0.1 Carbomer, sodium salt 0.1 0.1 0.1 0.2 0.1 Perfume q, s, q, s, q, s, q, s, q, s, iodopropynylbutylcarbamate 0,018 0,018 0,018 --- 0,018 water ad 100 ad 100 ad 100 ad 100 ad 100 56 57 58 59 60 Polyethylene glycol (40) stearate 1.0 --- 0.5 - - cyclomethicone 0.5 --- --- --- --- Icaridin 2 10 15 20 40 Perfume q, s, q, s, q, s, q, s, q, s, ethanol 15 20 30 40 20 methylparaben 0.4 0.1 0.05 0.3 0.4 marine extract --- --- 0.1 --- --- Aloe vera extract 0.1 --- 0.1 --- --- Hamamelis extract 0.1 --- 0.1 5 0.5 glycerin 5 10 3 15 7.5 Di-Trimethylolpropane 1.0 2.5 3.5 0.15 7.5 water ad 100 ad 100 ad 100 ad 100 ad 100 61 62 63 64 65 ethyl butylacetylaminopropionate 5 35 15 20 7.5 N, N-diethyltoluolamide 5 --- - 1 - Icaridin 5 3.0 2.0 1.5 12.5 1- (3-cyclohexen-1-yl-carbonyl) -2-methylpiperidine 5 --- 2 1 --- Hamamelis extract 0.2 --- --- 1 0.2 Aloe vera extract --- --- 1 1 5.0 tocopherol 0.5 0.5 0.75 0.25 0.1 marine extract 0.5 --- 0.75 3.0 0.25 panthenol 0.5 --- 0.75 0.25 0.1 Ethylhexylglycerin 1 1.5 0.5 0.75 10 Perfume q, s, q, s, q, s, q, s, q, s, sorbitol 10 --- - 5 --- butylene --- --- --- 5 10 propylene glycol --- --- 10 5 --- glycerin --- 7.5 --- --- --- water ad 100 ad 100 ad 100 ad 100 ad 100

Claims (5)

1. Packaging means made of high-density polyethylene (HDPE), comprising a cosmetic preparation comprising

   a) 2-(2-hydroxyethyl)-1-methylpropyl 1-piperidine carboxylate (INN: Icaridin) and

   b) one or more substances with a log P value of from -2.5 to +2.5, selected from the group of polyhydric alcohols, linear alcohols, branched alcohols, C5-C10 alkyl alcohols, polyglycerols.
2. Packaging means according to Claim 1, characterized in that the cosmetic preparation comprises 2-(2-hydroxyethyl)-1-methylpropyl 1-piperidine carboxylate (INN: Icaridin) and optionally further repellent active ingredients with a vapour pressure of at least 3.2 · 10^-4 hPa at 20°C in a total concentration of 1 to 40% by weight, based on the total weight of the preparation.
3. Packaging means according to one of the preceding claims, characterized in that the cosmetic preparation comprises substances with a log P value of from -2.5 to +2.5 in a total concentration of from 0.1 to 20% by weight, based on the total weight of the reparation.
4. Packaging means according to one of the preceding claims, characterized in that the weight ratio of the total amount of repellent active ingredients with a vapour pressure of at least 3.2 · 10^-4 hPa at 20°C to the total amount of substances with a log P value of from -2.5 to +2.5 is from 20:1 to 1:1.
5. Packaging means according to one of the preceding claims, characterized in that the cosmetic preparation is free from parabens.